Obstructive sleep apnea and twins

IF 1.8 4区医学 Q2 OTORHINOLARYNGOLOGY

American Journal of Otolaryngology Pub Date : 2026-09-01 Epub Date: 2026-08-31 DOI:10.1016/j.amjoto.2026.104919

Giannicola Iannella, Andrea Collettini, Antonella Polimeni, Armando De Virgilio, Patrizia Mancini, Annalisa Pace, Antonino Maniaci, Jerome R. Lechien, Carlos-Miguel Chiesa-Estomba, Luigi A. Vaira, Salvatore Cocuzza, Alberto Caranti, Claudio Vicini, Manuele Casale, Antonio Moffa, Mario Giuseppe Bellizzi, Enrica Croce, Saverio Nicoletti, Francesco Dispenza, Giuseppe Magliulo

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引用次数: 0

Abstract

Purpose

Present an intriguing case of a man suffering of OSA who has a homozygous monochorionic twin. Made a systematic review of the literature to summarize existing data and the reported incidence of OSA in twins.

Methods

Case presentation and systematic literature review, according to the PRISMA guidelines about twins and Obstructive sleep Apnea.

Results

Our patient had a severe OSA condition with an Apnea Hypopnea index (AHI) of 57.6. This patient had a twin who did not suffer from sleep apnea and presented different oropharyngeal and endoscopic anatomical characteristics. Six eligible studies were identified investigating OSA or OSA-related traits in twins. All studies demonstrated higher concordance among monozygotic than dizygotic twins and substantial heritability estimates (40%–83%), particularly for AHI and ODI. However, non-shared environmental and anatomical factors accounted for considerable phenotypic variability.

Conclusion

Despite the genetic factors related to the sleep apnea, differences in anatomical features and lifestyle could contributed to the different expression of OSA.

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阻塞性睡眠呼吸暂停和双胞胎。

目的：提出一个有趣的情况下，男子患阻塞性睡眠呼吸暂停谁有一个纯合子单绒毛膜双胞胎。对文献进行系统回顾，总结现有资料和已报道的双胞胎OSA发病率。方法：根据PRISMA关于双胞胎和阻塞性睡眠呼吸暂停的指南进行病例介绍和系统的文献复习。结果：患者重度OSA，呼吸暂停低通气指数（AHI）为57.6。该患者有一对双胞胎，他们没有睡眠呼吸暂停，但表现出不同的口咽和内窥镜解剖特征。确定了六项符合条件的研究，调查了双胞胎的OSA或OSA相关特征。所有研究都表明，同卵双胞胎的一致性高于异卵双胞胎，遗传率估计也很高（40%-83%），尤其是AHI和ODI。然而，非共享的环境和解剖因素占相当大的表型变异。结论：睡眠呼吸暂停与遗传因素有关，但解剖特征和生活方式的差异可能导致OSA的不同表达。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Otolaryngology 医学-耳鼻喉科学

CiteScore

4.40

自引率

4.00%

发文量

378

审稿时长

41 days

期刊介绍： Be fully informed about developments in otology, neurotology, audiology, rhinology, allergy, laryngology, speech science, bronchoesophagology, facial plastic surgery, and head and neck surgery. Featured sections include original contributions, grand rounds, current reviews, case reports and socioeconomics.