Kathryn E Lancaster, Melissa A Stockton, Judith A Hahn, Thida Chanyachukul, Ivan Marbaniang, Dhanushi Rupasinghe, Hai Thi Thanh Nguyen, Edith Kwobah, Helen Byakwaga, Aggrey Semeere, Suzanne Goodrich, Patrizia Carrieri, Gad Murenzi, Hugo Perazzo, Brenda Crabtree Ramírez, Jessica Mejía, Andreas D Haas, Ardele Mandiriri, Albert Minga, Marie Plaisy, Antoine Jaquet, Angela M Parcesepe
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引用次数: 0
Abstract
Measuring alcohol and other drug (AOD) use remains challenging in HIV care in low- and middle-income countries, where self-report and point-of-care (POC) urine biomarkers capture different time windows. Among 2,059 people with HIV aged 40 years or older across eight IeDEA clinics (2020 to 2022), we examined what self-reported AOD use (AUDIT, ASSIST) and POC urine tests (uEtG for alcohol; 5-panel drug screen) each capture. Self-report identified more use than urine testing (unhealthy alcohol 19.7% versus uEtG-positive 12.2%), consistent with its longer recall window. Higher self-reported alcohol intensity was associated with uEtG positivity in a graded pattern, more strongly among women. Urine-positive but self-report-negative results, more common among men, suggested under-reporting. Self-report and biomarkers answer different measurement questions: self-report for longer-term burden and screening, biomarkers for recent use and corroboration. Combining both, including longer-window biomarkers, can strengthen AOD measurement among older PWH in LMICs.
在低收入和中等收入国家的艾滋病毒护理中，测量酒精和其他药物（AOD）使用情况仍然具有挑战性，在这些国家，自我报告和护理点（POC）尿液生物标志物捕获不同的时间窗口。在8个IeDEA诊所（2020年至2022年）的2059名40岁或以上的艾滋病毒感染者中，我们检查了自我报告的AOD使用情况（AUDIT， ASSIST）和POC尿液测试（uEtG用于酒精；5组药物筛选）。与尿检相比，自我报告识别出更多的饮酒行为（不健康酒精19.7% vs uetg阳性12.2%），这与其更长的回忆窗口一致。较高的自我报告酒精浓度与uEtG阳性呈分级模式相关，在女性中更为明显。尿液呈阳性但自我报告阴性的结果在男性中更为常见，这表明报告不足。自我报告和生物标志物回答了不同的测量问题：长期负担和筛查的自我报告，近期使用和确证的生物标志物。结合两者，包括长窗口生物标志物，可以加强低收入国家老年PWH的AOD测量。
期刊介绍：
AIDS and Behavior provides an international venue for the scientific exchange of research and scholarly work on the contributing factors, prevention, consequences, social impact, and response to HIV/AIDS. This bimonthly journal publishes original peer-reviewed papers that address all areas of AIDS behavioral research including: individual, contextual, social, economic and geographic factors that facilitate HIV transmission; interventions aimed to reduce HIV transmission risks at all levels and in all contexts; mental health aspects of HIV/AIDS; medical and behavioral consequences of HIV infection - including health-related quality of life, coping, treatment and treatment adherence; and the impact of HIV infection on adults children, families, communities and societies. The journal publishes original research articles, brief research reports, and critical literature reviews. provides an international venue for the scientific exchange of research and scholarly work on the contributing factors, prevention, consequences, social impact, and response to HIV/AIDS. This bimonthly journal publishes original peer-reviewed papers that address all areas of AIDS behavioral research including: individual, contextual, social, economic and geographic factors that facilitate HIV transmission; interventions aimed to reduce HIV transmission risks at all levels and in all contexts; mental health aspects of HIV/AIDS; medical and behavioral consequences of HIV infection - including health-related quality of life, coping, treatment and treatment adherence; and the impact of HIV infection on adults children, families, communities and societies. The journal publishes original research articles, brief research reports, and critical literature reviews.5 Year Impact Factor: 2.965 (2008) Section ''SOCIAL SCIENCES, BIOMEDICAL'': Rank 5 of 29 Section ''PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH'': Rank 9 of 76
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