{"title":"Therapeutic drug monitoring of sertraline and clinical response","authors":"Y. W. Francis Lam Pharm.D., FCCP","doi":"10.1002/pu.31496","DOIUrl":null,"url":null,"abstract":"<p>Variability in drug exposure and response among individual patients can occur because of numerous factors, including age, sex, metabolic capacity, medication adherence, and the presence and magnitude of interactions with concurrently administered drugs. For decades, therapeutic drug monitoring with drug concentration determinations has been used to evaluate whether variability in drug exposure might be related to significant differences in therapeutic response to psychotropics (Hart et al., 2024; Kang & Lee, 2009).</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 10","pages":"2-3"},"PeriodicalIF":0.0000,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Brown University Psychopharmacology Update","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/pu.31496","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Variability in drug exposure and response among individual patients can occur because of numerous factors, including age, sex, metabolic capacity, medication adherence, and the presence and magnitude of interactions with concurrently administered drugs. For decades, therapeutic drug monitoring with drug concentration determinations has been used to evaluate whether variability in drug exposure might be related to significant differences in therapeutic response to psychotropics (Hart et al., 2024; Kang & Lee, 2009).
由于许多因素，包括年龄、性别、代谢能力、药物依从性以及与同时服用的药物相互作用的存在和程度，个体患者的药物暴露和反应可能存在差异。几十年来，通过药物浓度测定进行治疗药物监测一直用于评估药物暴露的可变性是否可能与精神药物治疗反应的显著差异有关（Hart et al., 2024; Kang & Lee, 2009）。
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