Dehydration-resistant multi-functional hydrogel-based iontophoretic drug delivery for wound healing

IF 13.8 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Nano Convergence Pub Date : 2026-08-31 DOI:10.1186/s40580-026-00572-y

Sang Hun Lee, Tae Hyeon Kim, Jae Wook Song, Na Yeon Kim, Ye-Jin Jo, Tae-Hyung Kim, Bong-Gun Ju, Bong Geun Chung

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Abstract

Wearable wound dressing is a promising approach for treating wound infection and promoting healing process. However, conventional wearable dressing methods have the drawback of poor long-term stability due to water loss. Herein, a novel hydrogel patch is fabricated by incorporating phosphoric acid and glycerol to enhance the water retention capacity. This hydrogel exhibits an excellent water retention rate of 97.7% after 7 days under ambient conditions (25 ℃, 50% relative humidity). Consequently, the stretchability, adhesion, and electrical conductivity required for wearable dressing are stably maintained. The antibiotic loaded into the dressing is effectively delivered via iontophoresis, which is demonstrated through in vitro drug release experiments, ex vivo porcine skin deposition tests, and in vivo mouse models. Therefore, this multi-functional hydrogel patch can be a promising strategy for developing an efficient drug delivery and wound healing platform using anti-drying conductive hydrogels and iontophoresis-based transdermal drug delivery.

Graphical abstract

查看原文本刊更多论文

抗脱水多功能水凝胶离子渗透药物在伤口愈合中的应用。

可穿戴伤口敷料是治疗伤口感染和促进愈合过程的一种很有前途的方法。然而，传统的可穿戴敷料方法由于水分流失，长期稳定性差。本文通过磷酸和甘油的掺入制备了一种新型的水凝胶贴片，以提高其保水能力。在环境条件（25℃，50%相对湿度）下，该水凝胶在7天后的保水率为97.7%。因此，稳定地保持了可穿戴敷料所需的拉伸性、粘附性和导电性。通过体外药物释放实验、猪离体皮肤沉积实验和小鼠体内模型，证明了敷料中负载的抗生素是通过离子透入的方式有效释放的。因此，这种多功能水凝胶贴片可以作为一种很有前途的策略，用于开发一种利用抗干燥导电水凝胶和基于离子电阻的透皮给药的高效药物传递和伤口愈合平台。

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来源期刊

Nano Convergence Engineering-General Engineering

CiteScore

15.90

自引率

2.60%

发文量

审稿时长

13 weeks

期刊介绍： Nano Convergence is an internationally recognized, peer-reviewed, and interdisciplinary journal designed to foster effective communication among scientists spanning diverse research areas closely aligned with nanoscience and nanotechnology. Dedicated to encouraging the convergence of technologies across the nano- to microscopic scale, the journal aims to unveil novel scientific domains and cultivate fresh research prospects. Operating on a single-blind peer-review system, Nano Convergence ensures transparency in the review process, with reviewers cognizant of authors' names and affiliations while maintaining anonymity in the feedback provided to authors.