Longitudinal Changes in Brain Volume and Magnetic Susceptibility Following CGRP Monoclonal Antibody Treatment in Patients With Migraine

IF 1.1 3区医学 Q2 CLINICAL NEUROLOGY

Acta Neurologica Scandinavica Pub Date : 2026-08-25 DOI:10.1155/ane/2670232

Yuya Kano, Yuto Uchida, Hirohito Kan, Keita Sakurai, Haruto Shibata, Mitsuharu Yamamoto, Koji Takada, Takao Takeshima, Noriyuki Matsukawa

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Abstract

Objective

The aim of this study was to evaluate cross-sectional and longitudinal changes in brain volume and magnetic susceptibility associated with treatment using calcitonin gene–related peptide monoclonal antibodies in patients with migraine.

Background

Calcitonin gene–related peptide monoclonal antibodies are effective in migraine prevention. However, because their primary action is peripheral, the extent of their influence on the central nervous system remains unclear.

Methods

Twenty-eight patients with migraine (18 responders and 10 nonresponders) underwent magnetic resonance imaging before and 6 months after treatment. Voxel-based analyses were performed using three-dimensional T1-weighted images and quantitative susceptibility mapping to assess brain volume and magnetic susceptibility, respectively. Cross-sectional analyses compared responders and nonresponders at each time point, whereas longitudinal analyses used subtraction images to evaluate alterations between pre- and post-treatment conditions.

Results

Cross-sectional analyses revealed no significant differences in brain volume or magnetic susceptibility between responders and nonresponders at either time point. Longitudinal morphometric analyses did not identify correction-surviving changes in gray matter volume or cortical thickness. At an exploratory voxel-level threshold, responders showed a greater longitudinal increase in magnetic susceptibility than nonresponders in the right calcarine sulcus extending into the visual association cortex (T = 4.24; MNI coordinates: x = 28, y = −68, z = 9), although this finding did not survive correction for multiple comparisons.

Conclusion

Calcitonin gene–related peptide monoclonal antibody treatment was not associated with correction-surviving structural morphometric changes over 6 months. An exploratory right calcarine susceptibility finding was observed in clinical responders, but its clinical significance remains unclear. These findings should be considered preliminary and require validation in larger longitudinal studies.

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偏头痛患者CGRP单克隆抗体治疗后脑容量和磁化率的纵向变化

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来源期刊

Acta Neurologica Scandinavica 医学-临床神经学

CiteScore

6.70

自引率

2.90%

发文量

161

审稿时长

4-8 weeks

期刊介绍： Acta Neurologica Scandinavica aims to publish manuscripts of a high scientific quality representing original clinical, diagnostic or experimental work in neuroscience. The journal''s scope is to act as an international forum for the dissemination of information advancing the science or practice of this subject area. Papers in English will be welcomed, especially those which bring new knowledge and observations from the application of therapies or techniques in the combating of a broad spectrum of neurological disease and neurodegenerative disorders. Relevant articles on the basic neurosciences will be published where they extend present understanding of such disorders. Priority will be given to review of topical subjects. Papers requiring rapid publication because of their significance and timeliness will be included as ''Clinical commentaries'' not exceeding two printed pages, as will ''Clinical commentaries'' of sufficient general interest. Debate within the speciality is encouraged in the form of ''Letters to the editor''. All submitted manuscripts falling within the overall scope of the journal will be assessed by suitably qualified referees.