Periodontal Disease is a Risk Factor for Placenta-Mediated Pregnancy Complications.

IF 1.8 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Journal of Nippon Medical School Pub Date : 2026-01-01 DOI:10.1272/jnms.JNMS.2026_93-408

Eriko Kikuchi, Asami Suzuki, Masako Hayashi, Atsuko Sekiguchi, Akihito Nakai, Shunji Suzuki

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引用次数: 0

Abstract

Objective: Although periodontal disease is known to be associated with obstetric complications, evidence is limited regarding the relationship with placenta-mediated pregnancy complications (PMPCs), a major cause of maternal and fetal morbidity and mortality. This study investigated whether periodontal disease is a risk factor for PMPCs.

Methods: We conducted a retrospective case-control study of inpatients with singleton pregnancies who underwent perinatal dental examinations at Nippon Medical School Tama Nagayama Hospital between September 2012 and August 2015. Medical records were reviewed for incident PMPCs, including preterm birth, preeclampsia, small for gestational age birth, placental abruption, and late pregnancy loss. Associations of periodontal disease with PMPCs were assessed using univariate and multivariate logistic regression analyses.

Results: Among 262 inpatients, 130 (49.6%) developed PMPCs. The prevalence of periodontal disease was significantly higher among women with PMPCs than among those without PMPCs (90.0% vs. 75.0%, P = 0.002). Multivariate logistic regression analysis identified periodontal disease as an independent risk factor for PMPCs (adjusted odds ratio [aOR], 2.89; 95% confidence interval [CI], 1.41-5.88). Younger maternal age (<35 years; aOR, 1.75; 95% CI, 1.04-2.92) and a past history of PMPCs (aOR, 3.27; 95% CI, 1.47-7.27) were also significantly associated with PMPCs.

Conclusion: Periodontal disease was independently associated with increased risk of PMPCs. Management of periodontal disease during pregnancy may help prevent PMPCs.

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牙周病是胎盘介导的妊娠并发症的危险因素。

目的：虽然已知牙周病与产科并发症有关，但关于其与胎盘介导的妊娠并发症（PMPCs）的关系的证据有限，PMPCs是孕产妇和胎儿发病率和死亡率的主要原因。本研究探讨牙周病是否是PMPCs的危险因素。方法：对2012年9月至2015年8月在日本医科大学多摩长山医院接受围产期牙科检查的单胎妊娠住院患者进行回顾性病例对照研究。我们回顾了PMPCs事件的医疗记录，包括早产、先兆子痫、小于胎龄分娩、胎盘早剥和晚期妊娠丢失。使用单变量和多变量logistic回归分析评估牙周病与PMPCs的关联。结果：262例住院患者中有130例（49.6%）发生PMPCs。有PMPCs的女性牙周病患病率明显高于无PMPCs的女性（90.0% vs. 75.0%, P = 0.002）。多因素logistic回归分析确定牙周病是PMPCs的独立危险因素（校正优势比[aOR]， 2.89； 95%可信区间[CI]， 1.41-5.88）。结论：牙周病与PMPCs风险增加独立相关。在怀孕期间管理牙周病可能有助于预防PMPCs。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nippon Medical School MEDICINE, GENERAL & INTERNAL-

CiteScore

1.80

自引率

10.00%

发文量

118

期刊介绍： The international effort to understand, treat and control disease involve clinicians and researchers from many medical and biological science disciplines. The Journal of Nippon Medical School (JNMS) is the official journal of the Medical Association of Nippon Medical School and is dedicated to furthering international exchange of medical science experience and opinion. It provides an international forum for researchers in the fields of bascic and clinical medicine to introduce, discuss and exchange thier novel achievements in biomedical science and a platform for the worldwide dissemination and steering of biomedical knowledge for the benefit of human health and welfare. Properly reasoned discussions disciplined by appropriate references to existing bodies of knowledge or aimed at motivating the creation of such knowledge is the aim of the journal.