Pregnancy Transiently Normalized Platelet Counts in Essential Thrombocytosis.

IF 1.8 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Journal of Nippon Medical School Pub Date : 2026-01-01 DOI:10.1272/jnms.JNMS.2026_93-411

Shunsuke Homma, Satoshi Wakita, Masahiro Sakaguchi, Shunsuke Yui, Koiti Inokuchi, Hiroki Yamaguchi

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引用次数: 0

Abstract

Background: Outcomes of pregnancies complicated by essential thrombocytosis (ET) are worse than those of normal pregnancies. Aspirin, heparin, and interferon (IFN)-α are well-tolerated during pregnancy and prescribed in accordance with the risk of thrombosis. However, some evidence suggests that platelet count decreases during ET-complicated pregnancies.

Methods: We retrospectively analyzed changes in platelet count in ET-complicated pregnancies.

Results: Platelet count decreased during pregnancy without IFN-α use, and 83% of pregnant women had a platelet count of ≤450×10⁹/L. Furthermore, all pregnant women achieved a platelet count of ≤600×10⁹/L. One the basis of revised IPSET-thrombosis score, risk was classified as low or very low. Aspirin use starting in early pregnancy was associated with a higher rate of successful delivery, even in patients with prior miscarriage.

Conclusions: These findings suggest that platelet counts decrease in selected low-risk and very-low-risk ET-complicated pregnancies and that cytoreductive therapy with IFN-α may be avoidable in some cases. These results should be interpreted cautiously because of the small sample size and retrospective study design.

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原发性血小板增多症的妊娠期短暂正常化血小板计数。

背景：妊娠合并原发性血小板增多症（ET）的结局比正常妊娠的结局更差。阿司匹林，肝素和干扰素(IFN)-α在怀孕期间耐受良好，并根据血栓形成的风险开处方。然而，一些证据表明血小板计数在et并发症妊娠期间减少。方法：回顾性分析et合并妊娠患者血小板计数的变化。结果：未使用IFN-α的妊娠期血小板计数下降，83%的孕妇血小板计数≤450×109/L。此外，所有孕妇的血小板计数均≤600×109/L。根据修订后的ipset血栓形成评分，风险分为低或极低。从怀孕早期开始服用阿司匹林与更高的成功分娩率相关，即使是有流产史的患者。结论：这些发现表明，在低风险和极低风险的et并发症妊娠中，血小板计数减少，在某些情况下，IFN-α的细胞减少治疗是可以避免的。由于样本量小和回顾性研究设计，这些结果应谨慎解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nippon Medical School MEDICINE, GENERAL & INTERNAL-

CiteScore

1.80

自引率

10.00%

发文量

118

期刊介绍： The international effort to understand, treat and control disease involve clinicians and researchers from many medical and biological science disciplines. The Journal of Nippon Medical School (JNMS) is the official journal of the Medical Association of Nippon Medical School and is dedicated to furthering international exchange of medical science experience and opinion. It provides an international forum for researchers in the fields of bascic and clinical medicine to introduce, discuss and exchange thier novel achievements in biomedical science and a platform for the worldwide dissemination and steering of biomedical knowledge for the benefit of human health and welfare. Properly reasoned discussions disciplined by appropriate references to existing bodies of knowledge or aimed at motivating the creation of such knowledge is the aim of the journal.