MINIMAL RESIDUAL DISEASE ASSESSMENT IN ACUTE LYMPHOBLASTIC LEUKEMIA: METHODS FOR DETECTION AND QUANTIFICATION.

Sara Addakiri, Hanaa Bencharef, Asmaa Harrach, Samiha Jaddaoui, Khadija Ait-Ichou, Bouchra Oukkache
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Abstract

Recently, the identification of minimal residual disease (MRD), also known as measurable residual disease, has seen significant advances driven by the evolving technological landscape in this field. Initially based on raw morphology, the field has since evolved to incorporate karyotyping, cytogenetics, flow cytometry, and other sensitive methods. This updated review discusses key technical considerations for successful MRD detection. We explore the correlation between the results obtained by flow cytometry and molecular genetic techniques.

急性淋巴细胞白血病最小残留病评估:检测和定量方法。
最近,微小残留病(MRD)的识别,也称为可测量残留病,在该领域不断发展的技术环境的推动下取得了重大进展。最初以原始形态学为基础,该领域已经发展到结合核型,细胞遗传学,流式细胞术和其他敏感方法。这篇更新的综述讨论了成功MRD检测的关键技术考虑因素。我们探讨了流式细胞术结果与分子遗传学技术之间的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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