Synergistic Topical Therapy Using Quercetin-silver Nanoparticles and Kaempferol Gel for Psoriasis Care.

Abstract

Introduction: The current era of nano drug delivery leverages nanoparticles to enhance the efficacy of plant-derived therapeutic agents. Recent studies indicate that silver nanoparticles (SNPs) serve as ideal carriers for drug delivery due to their versatile physicochemical properties. Quercetin is a major plant flavonoid used to treat psoriasis, wound healing, and inflammatory diseases, and has an inherent antimicrobial property.

Method: SNPs were prepared by a rapid one-pot synthesis method and characterized using FTIR, UV-Vis spectroscopy, and XRD analysis. Investigated the effectiveness of Quercetin silver nanoparticles (QSNPs) loaded Kaempferol (Kaempferol) gel against imiquimod (IMQ) induced psoriasis and inflammation.

Result: The Entrapment efficiency of the optimized formulation was found to be 86.78±0.08%. QSNP-loaded Kaempferol gel showed 82.28% cumulative drug release over the period of 24 hrs. The anti-inflammatory effect of the prepared gel formulation was evaluated using the in vitro HRBC membrane stabilization method and protein denaturation inhibition method.

Discussion: The bio-reduction of silver in SNPs due to Quercetin conjugation reduces toxicity, verified through skin irritancy assessments. QSNPs-loaded Kaempferol gel offered a noteworthy reduction in psoriasis area-severity index (PASI) scores in the IMQ-induced psoriasis model, which is ensured by a histopathology study.

Conclusion: Prepared QSNPs loaded Kaempferol gel shows promising effects against IMQinduced psoriasis and inflammation. Several patents and patent applications focus on the synthesis and application of quercetin silver nanoparticles.