Associations Between Choroidal Structural Parameters and Cone Photoreceptors in Young High Myopia.

IF 2.7 3区医学 Q2 OPHTHALMOLOGY

Translational Vision Science & Technology Pub Date : 2026-08-03 DOI:10.1167/tvst.15.8.21

Jingtao Yu, Zixun Wang, Luqiang Wang, Tingyu Zhang, Xiaoling Zhang, Zhiqing Li, Bei Du, Ruihua Wei

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引用次数: 0

Abstract

Purpose: To evaluate the association between choroidal structural parameters and cone photoreceptor characteristics in young individuals with different degrees of myopia and to assess whether choroidal thickness (CT) may indicate early photoreceptor alterations in high myopia (HM).

Methods: Ninety-three participants aged 18 to 28 years were classified as nonmyopic, mildly to moderately myopic, or highly myopic. CT and choroidal vascularity index (CVI) were measured using swept-source optical coherence tomography angiography. Cone metrics were quantified using adaptive optics scanning laser ophthalmoscopy with automated segmentation. Cone measurements were averaged across sampling locations to derive an overall value per eye. Group comparisons and associations were analyzed using appropriate parametric or nonparametric tests, correlation analysis, and multivariable linear regression.

Results: CT decreased progressively with increasing myopia across all macular regions (P < 0.001), while CVI showed no significant differences. Cone density was reduced in HM, with increased spacing and reduced regularity (P < 0.001). In unadjusted analyses, cone density was positively associated with CT (r = 0.313 to 0.394, P < 0.01). Each 1-µm increase in CT corresponded to an increase of approximately 10 to 12 cells/mm² in cone density.

Conclusions: Young HM eyes show concurrent reductions in CT and cone integrity, while CVI remains relatively stable. The observed associations likely reflect shared structural changes related to axial elongation rather than independent effects of CT.

Translational relevance: CT may serve as a practical structural biomarker for early retinal alterations in HM.

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青少年高度近视脉络膜结构参数与锥体光感受器的关系

目的：探讨不同近视程度的青少年视网膜脉络膜结构参数与视锥体光感受器特征的关系，并探讨脉络膜厚度（CT）是否可提示高度近视（HM）的早期光感受器改变。方法：93名年龄在18 ~ 28岁的参与者分为非近视、轻度至中度近视和高度近视。CT和脉络膜血管指数（CVI）测量扫描源光学相干断层扫描血管造影。采用自动分割的自适应光学扫描激光检眼镜对锥体指标进行量化。视锥测量值在采样位置上取平均值，以得出每只眼睛的总体值。使用适当的参数或非参数检验、相关分析和多变量线性回归分析组间比较和关联。结果：各黄斑区的CT随近视的增加而逐渐降低（P < 0.001），而CVI无显著差异。HM的锥体密度降低，间距增加，规律性降低（P < 0.001）。在未经校正的分析中，锥体密度与CT呈正相关（r = 0.313 ~ 0.394, P < 0.01）。CT每增加1µm，对应于锥密度增加约10至12个细胞/mm²。结论：年轻HM眼的CT和锥体完整性同时下降，而CVI保持相对稳定。观察到的关联可能反映了与轴向延伸相关的共同结构变化，而不是CT的独立影响。翻译相关性：CT可以作为HM早期视网膜改变的实用结构生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Vision Science & Technology Engineering-Biomedical Engineering

CiteScore

5.70

自引率

3.30%

发文量

346

审稿时长

25 weeks

期刊介绍： Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO. The journal covers a broad spectrum of work, including but not limited to: Applications of stem cell technology for regenerative medicine, Development of new animal models of human diseases, Tissue bioengineering, Chemical engineering to improve virus-based gene delivery, Nanotechnology for drug delivery, Design and synthesis of artificial extracellular matrices, Development of a true microsurgical operating environment, Refining data analysis algorithms to improve in vivo imaging technology, Results of Phase 1 clinical trials, Reverse translational ("bedside to bench") research. TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.