{"title":"Unlocking the Bioactive Potential of Streptomyces: A Multidisciplinary Approach to Strain Improvement","authors":"Anum Goraya, Anila Fariq, Aneela Fatima, Syed Hussain Imam Abidi, Sohail Ameer Marwat, Gholamreza Abdi","doi":"10.1002/mbo3.70379","DOIUrl":null,"url":null,"abstract":"<p><i>Streptomyces</i> is a genus of Gram-positive bacteria renowned for its remarkable ability to produce a diverse array of secondary metabolites (SMs), many of which possess significant pharmaceutical and agricultural value. Unlocking the full biopotential of <i>Streptomyces</i> is increasingly important in the quest for new therapeutics and sustainable solutions to global challenges, such as antibiotic resistance and food security. This review paper aims to bridge gaps in the literature by providing a comprehensive, integrative overview of recent advances in <i>Streptomyces</i> strain improvement. It discusses optimization of SM production in <i>Streptomyces</i> through a multidisciplinary approach. It also highlights the integration of traditional methods with modern genetic and metabolic engineering techniques to improve biosynthetic pathways, as well as adaptive laboratory evolution for strain development, systems, and fermentation, aiming to maximize the production of valuable bioactive compounds. While previous studies have explored individual aspects of strain optimization, this review presents a unified perspective on how these strategies can be applied effectively. This review not only enhances the understanding of <i>Streptomyces</i> biopotential but also addresses the need for a holistic framework that considers both established and emerging techniques in strain improvement. By filling these gaps, this review contributes to a more complete understanding of how to optimize <i>Streptomyces</i> for the production of valuable bioactive compounds, guiding future innovations and applications in biotechnology and pharmaceuticals.</p>","PeriodicalId":18573,"journal":{"name":"MicrobiologyOpen","volume":"15 4","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13501113/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"MicrobiologyOpen","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/mbo3.70379","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Streptomyces is a genus of Gram-positive bacteria renowned for its remarkable ability to produce a diverse array of secondary metabolites (SMs), many of which possess significant pharmaceutical and agricultural value. Unlocking the full biopotential of Streptomyces is increasingly important in the quest for new therapeutics and sustainable solutions to global challenges, such as antibiotic resistance and food security. This review paper aims to bridge gaps in the literature by providing a comprehensive, integrative overview of recent advances in Streptomyces strain improvement. It discusses optimization of SM production in Streptomyces through a multidisciplinary approach. It also highlights the integration of traditional methods with modern genetic and metabolic engineering techniques to improve biosynthetic pathways, as well as adaptive laboratory evolution for strain development, systems, and fermentation, aiming to maximize the production of valuable bioactive compounds. While previous studies have explored individual aspects of strain optimization, this review presents a unified perspective on how these strategies can be applied effectively. This review not only enhances the understanding of Streptomyces biopotential but also addresses the need for a holistic framework that considers both established and emerging techniques in strain improvement. By filling these gaps, this review contributes to a more complete understanding of how to optimize Streptomyces for the production of valuable bioactive compounds, guiding future innovations and applications in biotechnology and pharmaceuticals.
期刊介绍：
MicrobiologyOpen is a peer reviewed, fully open access, broad-scope, and interdisciplinary journal delivering rapid decisions and fast publication of microbial science, a field which is undergoing a profound and exciting evolution in this post-genomic era.
The journal aims to serve the research community by providing a vehicle for authors wishing to publish quality research in both fundamental and applied microbiology. Our goal is to publish articles that stimulate discussion and debate, as well as add to our knowledge base and further the understanding of microbial interactions and microbial processes.
MicrobiologyOpen gives prompt and equal consideration to articles reporting theoretical, experimental, applied, and descriptive work in all aspects of bacteriology, virology, mycology and protistology, including, but not limited to:
- agriculture
- antimicrobial resistance
- astrobiology
- biochemistry
- biotechnology
- cell and molecular biology
- clinical microbiology
- computational, systems, and synthetic microbiology
- environmental science
- evolutionary biology, ecology, and systematics
- food science and technology
- genetics and genomics
- geobiology and earth science
- host-microbe interactions
- infectious diseases
- natural products discovery
- pharmaceutical and medicinal chemistry
- physiology
- plant pathology
- veterinary microbiology
We will consider submissions across unicellular and cell-cluster organisms: prokaryotes (bacteria, archaea) and eukaryotes (fungi, protists, microalgae, lichens), as well as viruses and prions infecting or interacting with microorganisms, plants and animals, including genetic, biochemical, biophysical, bioinformatic and structural analyses.
The journal features Original Articles (including full Research articles, Method articles, and Short Communications), Commentaries, Reviews, and Editorials. Original papers must report well-conducted research with conclusions supported by the data presented in the article. We also support confirmatory research and aim to work with authors to meet reviewer expectations.
MicrobiologyOpen publishes articles submitted directly to the journal and those referred from other Wiley journals.
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