Palatal Donor-Site Healing and Patient-Reported Outcome Measures Following Chitosan and Injectable Platelet-Rich Fibrin-Enriched Chitosan Application Compared with Gelatine Sponge: A Three-Arm Randomised Controlled Clinical Trial

IF 8.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology Pub Date : 2026-10-12 Epub Date: 2026-08-23 DOI:10.1111/jcpe.70194

Ayse Ege Selman, Bahar Alkaya, Burcu Karaduman, Mustafa Ozcan, Mehmet Cenk Haytac

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引用次数: 0

Abstract

Aim

To compare clinical outcomes and patient-reported outcome measures (PROMs) of palatal donor-site healing following the use of an absorbable gelatine sponge, a chitosan sponge or an injectable platelet-rich fibrin (i-PRF)-enriched chitosan sponge after free gingival graft harvesting.

Materials and Methods

In this three-arm randomised controlled clinical study, a total of 68 patients were allocated to three groups: i-PRF + chitosan (n = 22), chitosan (n = 23) and gelatine sponge (control; n = 23). The primary outcome was the palatal early healing index (PEHI). Secondary outcomes included PROMs, namely postoperative pain, burning sensation and changes in dietary habits, which were evaluated using a visual analogue scale (VAS) at postoperative days 7, 14, 28 and 56. Bleeding and painkiller consumption were recorded daily. Colour match was assessed using VAS.

Results

Both chitosan-containing groups showed significantly higher PEHI scores, particularly on days 14 and 28, than the control group (p < 0.001). At Day 14, the median PEHI scores were 8.0 (Q1–Q3: 7.0–8.0; 95% CI for the median: 7.0–8.0), 8.0 (Q1–Q3: 8.0–9.0; 95% CI: 8.0–9.0) and 9.0 (Q1–Q3:8.0–9.0; 95% CI: 8.0–9.0) in the control, chitosan and i-PRF-enriched chitosan groups, respectively. The i-PRF + chitosan group showed significantly lower pain and burning sensation during early healing and less changes on dietary habits on days 3 and 7 compared with the other groups (p < 0.05). Bleeding and painkiller consumption were similar among groups (p > 0.05). Both test groups showed significantly better colour match than the control group at days 14, 28 and 56 (p < 0.001).

Conclusion

Within the limitations of the present study, chitosan improved early palatal wound healing, while the addition of i-PRF enhanced patient comfort. Both chitosan-containing approaches resulted in improved colour match compared with control. Nevertheless, further studies incorporating histological and biomolecular assessments of wound healing are needed to confirm these findings.

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与明胶海绵相比，壳聚糖和注射富血小板纤维蛋白壳聚糖后腭供体部位愈合和患者报告的结果：一项三组随机对照临床试验。

目的：比较游离牙龈移植术后使用可吸收性明胶海绵、壳聚糖海绵或可注射富血小板纤维蛋白（i-PRF）壳聚糖海绵后腭供区愈合的临床结果和患者报告的预后指标（PROMs）。材料和方法：在这项三组随机对照临床研究中，共有68例患者被分为三组：i-PRF +壳聚糖（n = 22）、壳聚糖（n = 23）和明胶海绵（n = 23）。主要观察指标为腭早期愈合指数（PEHI）。次要结果包括PROMs，即术后疼痛、烧灼感和饮食习惯的变化，在术后第7、14、28和56天使用视觉模拟量表（VAS）进行评估。每天记录出血和止痛药用量。采用VAS评估颜色匹配。结果：两组小鼠PEHI评分均显著高于对照组，特别是第14天和第28天（p 0.05）。两个试验组在第14、28和56天的颜色匹配都明显优于对照组(p结论：在本研究的局限性内，壳聚糖改善了早期腭面伤口愈合，而i-PRF的加入提高了患者的舒适度。与对照组相比，两种含壳聚糖的方法都改善了颜色匹配。然而，需要进一步的研究结合伤口愈合的组织学和生物分子评估来证实这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Periodontology 医学-牙科与口腔外科

CiteScore

13.30

自引率

10.40%

发文量

175

审稿时长

3-8 weeks

期刊介绍： Journal of Clinical Periodontology was founded by the British, Dutch, French, German, Scandinavian, and Swiss Societies of Periodontology. The aim of the Journal of Clinical Periodontology is to provide the platform for exchange of scientific and clinical progress in the field of Periodontology and allied disciplines, and to do so at the highest possible level. The Journal also aims to facilitate the application of new scientific knowledge to the daily practice of the concerned disciplines and addresses both practicing clinicians and academics. The Journal is the official publication of the European Federation of Periodontology but wishes to retain its international scope. The Journal publishes original contributions of high scientific merit in the fields of periodontology and implant dentistry. Its scope encompasses the physiology and pathology of the periodontium, the tissue integration of dental implants, the biology and the modulation of periodontal and alveolar bone healing and regeneration, diagnosis, epidemiology, prevention and therapy of periodontal disease, the clinical aspects of tooth replacement with dental implants, and the comprehensive rehabilitation of the periodontal patient. Review articles by experts on new developments in basic and applied periodontal science and associated dental disciplines, advances in periodontal or implant techniques and procedures, and case reports which illustrate important new information are also welcome.