{"title":"Advances in Biosensing Methods for Lactate Detection","authors":"Haolin Xin, Yingkai Qin, Aili Wei, Tianhui Wang","doi":"10.1134/S106193482670070X","DOIUrl":null,"url":null,"abstract":"<div><p>Lactate functions as a central hub for energy metabolism, a cellular communication mediator, and a critical node in disease progression. Its pivotal role across healthcare, sports science, and food industries drives innovations in detection technologies. While conventional methods (chromatography, enzymatic assays, voltammetry) offer moderate precision, they face limitations including inadequate specificity, costly instrumentation, and cumbersome procedures. Biosensors have emerged as transformative solutions due to high sensitivity, rapid response, and miniaturization capabilities, finding broad application in medical diagnostics and environmental monitoring. This review comprehensively examines advances in lactate biosensing—focusing on electrochemical and optical sensing approaches alongside wearable/implantable platforms—while addressing critical bottlenecks and future development trajectories.</p></div>","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"81 :","pages":"1371 - 1379"},"PeriodicalIF":1.5000,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Analytical Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S106193482670070X","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Lactate functions as a central hub for energy metabolism, a cellular communication mediator, and a critical node in disease progression. Its pivotal role across healthcare, sports science, and food industries drives innovations in detection technologies. While conventional methods (chromatography, enzymatic assays, voltammetry) offer moderate precision, they face limitations including inadequate specificity, costly instrumentation, and cumbersome procedures. Biosensors have emerged as transformative solutions due to high sensitivity, rapid response, and miniaturization capabilities, finding broad application in medical diagnostics and environmental monitoring. This review comprehensively examines advances in lactate biosensing—focusing on electrochemical and optical sensing approaches alongside wearable/implantable platforms—while addressing critical bottlenecks and future development trajectories.
期刊介绍：
The Journal of Analytical Chemistry is an international peer reviewed journal that covers theoretical and applied aspects of analytical chemistry; it informs the reader about new achievements in analytical methods, instruments and reagents. Ample space is devoted to problems arising in the analysis of vital media such as water and air. Consideration is given to the detection and determination of metal ions, anions, and various organic substances. The journal welcomes manuscripts from all countries in the English or Russian language.
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