Beyond differential expression: Differential variability as an underappreciated axis in transcriptomics.

IF 7.7
Chenxin Flora Jiang, Changhu Wang, Jingyi Jessica Li
{"title":"Beyond differential expression: Differential variability as an underappreciated axis in transcriptomics.","authors":"Chenxin Flora Jiang, Changhu Wang, Jingyi Jessica Li","doi":"10.1016/j.cels.2026.101706","DOIUrl":null,"url":null,"abstract":"<p><p>Differential expression has long been the default lens for comparing transcriptomes between conditions, but mean shifts alone can miss important biological signals. Using a recent debate on memory-associated transcriptome changes, this commentary highlights differential variability as an underappreciated axis for interpreting transcriptome variation.</p>","PeriodicalId":93929,"journal":{"name":"Cell systems","volume":"17 8","pages":"101706"},"PeriodicalIF":7.7000,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13533298/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell systems","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.cels.2026.101706","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Differential expression has long been the default lens for comparing transcriptomes between conditions, but mean shifts alone can miss important biological signals. Using a recent debate on memory-associated transcriptome changes, this commentary highlights differential variability as an underappreciated axis for interpreting transcriptome variation.

超越差异表达:转录组学中未被充分认识的差异变异性。
长期以来,差异表达一直是比较不同条件下转录组的默认镜头,但平均变化本身可能会错过重要的生物信号。利用最近关于记忆相关转录组变化的辩论,这篇评论强调了差异变异性作为解释转录组变化的一个未被充分认识的轴。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书