Chenxin Flora Jiang, Changhu Wang, Jingyi Jessica Li
{"title":"Beyond differential expression: Differential variability as an underappreciated axis in transcriptomics.","authors":"Chenxin Flora Jiang, Changhu Wang, Jingyi Jessica Li","doi":"10.1016/j.cels.2026.101706","DOIUrl":null,"url":null,"abstract":"<p><p>Differential expression has long been the default lens for comparing transcriptomes between conditions, but mean shifts alone can miss important biological signals. Using a recent debate on memory-associated transcriptome changes, this commentary highlights differential variability as an underappreciated axis for interpreting transcriptome variation.</p>","PeriodicalId":93929,"journal":{"name":"Cell systems","volume":"17 8","pages":"101706"},"PeriodicalIF":7.7000,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13533298/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell systems","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.cels.2026.101706","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Differential expression has long been the default lens for comparing transcriptomes between conditions, but mean shifts alone can miss important biological signals. Using a recent debate on memory-associated transcriptome changes, this commentary highlights differential variability as an underappreciated axis for interpreting transcriptome variation.