Regional amyloid accumulation, post-traumatic distress, and intrusive symptoms in cognitively unimpaired older adults at risk for Alzheimer's.

IF 4.4 Q1 CLINICAL NEUROLOGY

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-18 eCollection Date: 2026-07-01 DOI:10.1002/dad2.70410

Eleni Palpatzis, Carmen M Colceriu, Mahnaz Shekari, Muge Akinci, Marc Suárez-Calvet, Oriol Grau-Rivera, Gonzalo Sánchez-Benavides, Juan Domingo Gispert, Eider M Arenaza-Urquijo

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引用次数: 0

Abstract

Introduction: In preclinical Alzheimer's disease (AD), early pathology may heighten vulnerability to psychiatric symptoms. We examined whether Aβ accumulation in cognitive-emotional regions was associated with post-pandemic psychiatric symptoms.

Methods: This prospective cohort study included 115 cognitively unimpaired ALzheimer's and FAmilies participants (69 [60%] women, mean [SD] age 64.9 [4.8] years). Amyloid beta (Aβ) change was examined in anterior cingulate, posterior cingulate, superior parietal, medial orbitofrontal gyri, and insula using two [18F]flutemetamol positron emission tomography (PET) scans. Outcomes were pandemic-related post-traumatic distress (Impact of Events Scale Revised [IES-R]; total, intrusive, avoidance, and hyperarousal symptoms) and anxious-depressive symptoms (Hospital Anxiety and Depression Scale [HADS]; mean follow-up: 3.62 years [SD = 0.68]). Linear regression and voxel-wise analyses were performed.

Results: Aβ accumulation across anterior cingulate (β = 40.29, p = 0.036), posterior cingulate (β = 29.52, p = 0.012), superior parietal (β = 35.58, p = 0.036), and medial orbitofrontal gyri (β = 35.08, p = 0.036) was associated with post-pandemic intrusive symptoms only, independent of baseline anxious-depressive symptoms.

Discussion: Aβ accumulation in cognitive-emotional regions may increase vulnerability to intrusive symptoms, highlighting their potential as early clinical markers in AD.

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有阿尔茨海默氏症风险的认知未受损老年人的区域性淀粉样蛋白积累、创伤后应激和侵入性症状

在临床前阿尔茨海默病（AD）中，早期病理可能会增加对精神症状的易感性。我们研究了认知-情绪区域的Aβ积累是否与大流行后精神症状有关。方法：该前瞻性队列研究纳入115名认知功能未受损的阿尔茨海默病患者及其家庭参与者（69名[60%]女性，平均[SD]年龄64.9[4.8]岁）。采用两种[18F]氟替美莫正电子发射断层扫描（PET）检查前扣带、后扣带、上顶叶、内侧眶额回和脑岛的β淀粉样蛋白（Aβ）变化。结果是与流行病相关的创伤后应激（事件影响量表修订版[es -r]；总症状、侵入性症状、回避症状和高唤醒症状）和焦虑抑郁症状（医院焦虑抑郁量表[HADS]；平均随访时间：3.62年[SD = 0.68]）。进行了线性回归和体素分析。结果：Aβ在前扣带（β = 40.29, p = 0.036）、后扣带（β = 29.52, p = 0.012）、顶叶上（β = 35.58, p = 0.036）和眶额内侧回（β = 35.08, p = 0.036）的积累仅与大流行后侵入性症状相关，与基线焦虑抑郁症状无关。讨论：Aβ在认知情绪区域的积累可能增加对侵入性症状的易感性，突出了它们作为AD早期临床标志物的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Medicine-Psychiatry and Mental Health

CiteScore

7.80

自引率

7.50%

发文量

101

审稿时长

8 weeks

期刊介绍： Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.