Life's Essential 8™ and incident dementia in an urban cohort: Findings from the Northern Manhattan Study.

IF 4.4 Q1 CLINICAL NEUROLOGY

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-18 eCollection Date: 2026-07-01 DOI:10.1002/dad2.70444

Erin-Leigh Gallop, Pooja Kondeti, Hannah Gardener, Tatjana Rundek, Jose Gutierrez, Mitchell S V Elkind, Clinton B Wright, Bonnie Levin, Lily Wang, Christian Agudelo, Stephanie Assuras, Vanessa Guzman, Tali Elfassy

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引用次数: 0

Abstract

Introduction: The American Heart Association's Life's Essential 8™ (LE8) defines cardiovascular health (CVH) using eight behavioral and clinical metrics. We examined the association between CVH and incident dementia.

Methods: We used data from 920 dementia-free participants of the Northern Manhattan Study. LE8 scores (range: 0-100) were calculated from information on clinical and behavioral characteristics. Dementia was adjudicated by expert clinicians using neuropsychological assessments and clinical records. We used Cox proportional hazards models to determine associations adjusting for age, sex, race/ethnicity, education, and insurance.

Results: Mean age was 64 years, 60% of participants were female, 65% were Hispanic, and mean LE8 score was 60. Over 9 years, 175 participants developed dementia. Each 10-unit decrement in LE8 score was associated with a greater risk of dementia (hazard ratio [HR]: 1.33; 95% confidence interval [CI]: 1.17-1.51).

Discussion: CVH is important for brain health, and our results support interventions aimed at improving CVH for prevention of dementia.

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生活必需品™和城市队列中的痴呆事件：来自北曼哈顿研究的发现。

简介：美国心脏协会的生命基本8™（LE8）定义心血管健康（CVH）使用八个行为和临床指标。我们研究了CVH和痴呆之间的关系。方法：我们使用了920名来自北曼哈顿研究的无痴呆参与者的数据。LE8评分（范围：0-100）根据临床和行为特征信息计算。痴呆症由专家临床医生根据神经心理学评估和临床记录进行裁决。我们使用Cox比例风险模型来确定调整年龄、性别、种族/民族、教育和保险后的相关性。结果：参与者平均年龄64岁，60%为女性，65%为西班牙裔，平均LE8评分为60分。在9年的时间里，175名参与者患上了痴呆症。LE8评分每降低10个单位，痴呆风险增加（风险比[HR]: 1.33； 95%可信区间[CI]: 1.17-1.51）。讨论：CVH对大脑健康很重要，我们的研究结果支持旨在改善CVH预防痴呆的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Medicine-Psychiatry and Mental Health

CiteScore

7.80

自引率

7.50%

发文量

101

审稿时长

8 weeks

期刊介绍： Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.