Prevalence, antimicrobial resistance, and risk factors of bacterial urinary tract infections among asymptomatic diabetes mellitus patients in Bahir Dar, Ethiopia.

IF 2.1 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Journal of Public Health Research Pub Date : 2026-08-17 eCollection Date: 2026-07-01 DOI:10.1177/22799036261480185

Alemayehu Abate, Melkamnesh Azage, Abaineh Munshea

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引用次数: 0

Abstract

Introduction: Diabetes mellitus associated with urinary tract infections. This study aimed to determine the prevalence of bacterial infection of urinary tract, assess antimicrobial resistance, and associated factors among asymptomatic diabetic patients attending Felege Hiwot Comprehensive Specialized Hospital, Bahir Dar, northwestern Ethiopia.

Methods: An institution-based cross-sectional study was conducted from January to March 2025 among 248 diabetic patients. Sociodemographic and clinical data were collected using a structured questionnaire. Data were entered into EPI data 3.1 and exported to SPSS v.26. Bivariate and multivariable logistic regression analyses were used to identify factors associated with bacterial infection of urinary tract, with p < 0.05 considered statistically significant.

Results: Of the 248 study participants, 63 (25.4%) had bacterial infection of urinary tract. Gram-negative bacteria predominated, with Escherichia coli (38.1%), Klebsiella pneumoniae (20.6%), and Acinetobacter baumannii (11.1%) being the most common isolates. High resistance was observed to commonly used antibiotics, including ampicillin, amoxicillin-clavulanate, chloramphenicol, and co-trimoxazole. In multivariable analysis, age 19-60 years (AOR = 3.95; 95% CI: 1.55-10.08), divorced marital status (AOR = 3.05; 95% CI: 1.02-9.09), prior history of UTI (AOR = 2.20; 95% CI: 1.12-4.33), and longer duration of diabetes (6-10 years: AOR = 3.85; >10 years: AOR = 5.50) were significantly associated with bacterial infection of urinary tract.

Conclusion: The findings of this study showed bacterial infection of urinary tract is common among asymptomatic diabetic patients, with a high burden of antimicrobial resistance. Antimicrobial stewardship programs, rational antibiotic use guided by culture and sensitivity testing are essential to reduce infection-related morbidity.

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埃塞俄比亚巴希尔达尔无症状糖尿病患者细菌性尿路感染的患病率、抗菌素耐药性和危险因素

导读：糖尿病伴尿路感染。本研究旨在确定在埃塞俄比亚西北部Bahir Dar的felge Hiwot综合专科医院就诊的无症状糖尿病患者尿路细菌感染的患病率，评估抗菌药物耐药性及其相关因素。方法：对2025年1 - 3月248例糖尿病患者进行机构横断面研究。采用结构化问卷收集社会人口学和临床数据。数据输入EPI Data 3.1，导出到SPSS v.26。采用双变量和多变量logistic回归分析确定尿路细菌感染的相关因素，p < 0.05认为有统计学意义。结果：在248名研究参与者中，63人（25.4%）有尿路细菌感染。革兰氏阴性菌占多数，其中大肠杆菌（38.1%）、肺炎克雷伯菌（20.6%）和鲍曼不动杆菌（11.1%）是最常见的分离株。对常用抗生素，包括氨苄西林、阿莫西林-克拉维酸酯、氯霉素和复方新诺明均有高耐药性。在多变量分析中，年龄19 ~ 60岁（AOR = 3.95; 95% CI: 1.55 ~ 10.08）、离婚婚姻状况（AOR = 3.05; 95% CI: 1.02 ~ 9.09）、既往尿路感染史（AOR = 2.20; 95% CI: 1.12 ~ 4.33）、糖尿病病程较长（6 ~ 10年：AOR = 3.85； 10年：AOR = 5.50）与尿路细菌感染显著相关。结论：尿路细菌感染在无症状糖尿病患者中较为常见，且耐药负担较高。抗菌药物管理方案，合理使用抗生素指导下培养和敏感性试验是必不可少的，以减少感染相关的发病率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Public Health Research PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

3.70

自引率

4.30%

发文量

116

审稿时长

10 weeks

期刊介绍： The Journal of Public Health Research (JPHR) is an online Open Access, peer-reviewed journal in the field of public health science. The aim of the journal is to stimulate debate and dissemination of knowledge in the public health field in order to improve efficacy, effectiveness and efficiency of public health interventions to improve health outcomes of populations. This aim can only be achieved by adopting a global and multidisciplinary approach. The Journal of Public Health Research publishes contributions from both the “traditional'' disciplines of public health, including hygiene, epidemiology, health education, environmental health, occupational health, health policy, hospital management, health economics, law and ethics as well as from the area of new health care fields including social science, communication science, eHealth and mHealth philosophy, health technology assessment, genetics research implications, population-mental health, gender and disparity issues, global and migration-related themes. In support of this approach, JPHR strongly encourages the use of real multidisciplinary approaches and analyses in the manuscripts submitted to the journal. In addition to Original research, Systematic Review, Meta-analysis, Meta-synthesis and Perspectives and Debate articles, JPHR publishes newsworthy Brief Reports, Letters and Study Protocols related to public health and public health management activities.