Multicenter ProKnow-based plan evaluation of postprostatectomy salvage radiotherapy patients using SPPORT and RADICALS-HD trial-defined dose constraints.

IF 2.8 3区医学 Q3 ONCOLOGY

Strahlentherapie und Onkologie Pub Date : 2026-08-20 DOI:10.1007/s00066-026-02584-3

Michael Keilholz, Erik F Moar, Frederike Brose, Sebastian H Maier, Claus Belka, Paul Rogowski, Matthias Zähringer, Jan C Peeken, Stephanie E Combs, Stephan Schönecker, Florian Putz, Christoph Süß, Marius Treutwein, Vasiliki Angnostatou, Nina Schmidt-Hegemann

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引用次数: 0

Abstract

Purpose: Salvage radiotherapy (sRT) after radical prostatectomy is the only curative treatment for patients with biochemical recurrence. Sparing organs at risk (OAR) is essential to minimize long-term toxicity. This multicenter study analyzed radiotherapy plans from Bavarian university centers within the Bavarian Cancer Research Center (BZKF) using dose-volume constraints from the SPPORT and RADICALS-HD trials.

Methods: In this retrospective multicenter analysis, 117 patients treated with prostate bed sRT were included. Radiotherapy plans were anonymized and evaluated using ProKnow (Elekta, Stockholm, Sweden). Scorecards based on SPPORT and RADICALS-HD dose-volume constraints were used to assess plan quality. Planning metrics, including planning target volume (PTV), D95, conformality index, and V66, were recorded, and their correlations with OAR dose were analyzed.

Results: The median PTV was 213.9 cm³ (interquartile range [IQR] 154.4-267.8 cm³), with a median D95 of 64.5 Gy (IQR 63.7-67.1 Gy). The median volume receiving 66 Gy (V66) was 192.62 cm³ (IQR 146.59-244.49 cm³). Bladder dose constraints were met in 92-100% of plans according to RADICALS-HD and in 89-97% according to SPPORT. Rectal constraints were fulfilled in 98-100% and 95-100% of plans, respectively. All femoral head plans met the SPPORT V50 constraint. Correlation analyses showed weak associations with bladder dose and weak-to-moderate associations with rectal dose.

Conclusion: This multicenter analysis demonstrates that dose-volume objectives in the postoperative salvage setting can be reliably assessed across centers and are met in the majority of cases. ProKnow enables structured and objective plan evaluation and serves as a useful tool for standardized quality assurance.

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使用SPPORT和radical - hd试验确定的剂量限制对前列腺切除术后补救性放疗患者的多中心proknow计划评估。

目的：根治性前列腺切除术后补救性放疗（sRT）是治疗生化复发的唯一方法。保留危险器官（OAR）对于减少长期毒性至关重要。这项多中心研究分析了巴伐利亚癌症研究中心（BZKF）内巴伐利亚大学中心的放疗计划，使用了SPPORT和radical - hd试验的剂量-体积限制。方法：回顾性多中心分析117例接受前列腺床sRT治疗的患者。放疗计划匿名化并使用ProKnow （Elekta, Stockholm, Sweden）进行评估。使用基于SPPORT和radical - hd剂量-体积约束的记分卡评估计划质量。记录规划指标，包括规划靶体积（PTV）、D95、一致性指数和V66，并分析其与OAR剂量的相关性。结果：中位PTV为213.9 cm3（四分位间距[IQR] 154.4-267.8 cm3），中位D95为64.5 Gy （IQR 63.7-67.1 Gy）。接受66 Gy的中位容积（V66）为192.62 cm3 （IQR 146.59-244.49 cm3）。根据radical - hd，膀胱剂量限制在92% -100%的计划中得到满足，根据SPPORT，在89% -97%的计划中得到满足。直肠约束的满足率分别为98-100%和95-100%。所有股骨头计划均符合SPPORT V50限制。相关分析显示与膀胱剂量的相关性较弱，与直肠剂量的相关性较弱至中等。结论：这项多中心分析表明，术后抢救设置中的剂量-体积目标可以可靠地跨中心评估，并在大多数情况下得到满足。ProKnow支持结构化和客观的计划评估，并作为标准化质量保证的有用工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Strahlentherapie und Onkologie 医学-核医学

CiteScore

5.70

自引率

12.90%

发文量

141

审稿时长

3-8 weeks

期刊介绍： Strahlentherapie und Onkologie, published monthly, is a scientific journal that covers all aspects of oncology with focus on radiooncology, radiation biology and radiation physics. The articles are not only of interest to radiooncologists but to all physicians interested in oncology, to radiation biologists and radiation physicists. The journal publishes original articles, review articles and case studies that are peer-reviewed. It includes scientific short communications as well as a literature review with annotated articles that inform the reader on new developments in the various disciplines concerned and hence allow for a sound overview on the latest results in radiooncology research. Founded in 1912, Strahlentherapie und Onkologie is the oldest oncological journal in the world. Today, contributions are published in English and German. All articles have English summaries and legends. The journal is the official publication of several scientific radiooncological societies and publishes the relevant communications of these societies.