Youngoh Bae, Seondeok Seo, Daewon Yang, Hohyun Jung, Seung Won Lee
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引用次数: 0
Abstract
Objective: Psychotic symptoms are common in Parkinson's disease (PD), yet it remains unclear whether these manifestations reflect transient, medication-related phenomena or an increased risk of clinically diagnosed schizophrenia spectrum disorders (SSD). This study aimed to evaluate the long-term risk of incident SSD following PD using a nationwide population-based cohort and to assess whether this risk varies across demographic, lifestyle, and metabolic subgroups.
Methods: We conducted a retrospective cohort study using the Korean National Health Insurance Service database from 2012 to 2023. Individuals newly diagnosed with PD were identified using repeated International Classification of Diseases, 10th Revision (ICD-10) codes and matched 1:5 with controls using propensity scores. Incident SSD was defined by repeated ICD-10 diagnoses. Incidence rates, incidence rate ratios, Kaplan-Meier curves, and Cox proportional hazards models were used.
Results: Among 5,110 patients with PD and 25,550 matched controls, 128 and 177 incident cases of SSD were identified, respectively. The incidence rate of SSD was higher in the PD group than in controls (7.09 vs. 1.75 per 1,000 person-years), yielding an IRR of 4.06 (95% confidence interval [CI], 3.23-5.09). PD was associated with an increased risk of SSD after multivariable adjustment (adjusted hazard ratio 4.90; 95% CI, 3.52-6.81), with particularly elevated risk among individuals younger than 60 years.
Conclusion: PD was associated with a substantially increased long-term risk of SSD. These findings suggest that psychotic manifestations following PD may reflect persistent psychiatric morbidity rather than transient symptoms alone.
期刊介绍：
The Psychiatry Investigation is published on the 25th day of every month in English by the Korean Neuropsychiatric Association (KNPA). The Journal covers the whole range of psychiatry and neuroscience. Both basic and clinical contributions are encouraged from all disciplines and research areas relevant to the pathophysiology and management of neuropsychiatric disorders and symptoms, as well as researches related to cross cultural psychiatry and ethnic issues in psychiatry. The Journal publishes editorials, review articles, original articles, brief reports, viewpoints and correspondences. All research articles are peer reviewed. Contributions are accepted for publication on the condition that their substance has not been published or submitted for publication elsewhere. Authors submitting papers to the Journal (serially or otherwise) with a common theme or using data derived from the same sample (or a subset thereof) must send details of all relevant previous publications and simultaneous submissions. The Journal is not responsible for statements made by contributors. Material in the Journal does not necessarily reflect the views of the Editor or of the KNPA. Manuscripts accepted for publication are copy-edited to improve readability and to ensure conformity with house style.
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