Kumara Datta Mahesh A, Mousumi Namasudra, Camelia Manna, Saktipada Pradhan, Rabindra Nath Hansda, Sadhan Bag, Samiran Mondal, Kinsuk Das
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引用次数: 0
Abstract
The goal of skin tissue regeneration is to achieve structural and functional reconstruction, reduce scar formation, and improve wound healing quality. The present study highlights the wound healing and tissue regeneration capability of bovine umbilical cord-derived mesenchymal stem cells (bUC-MSCs) and its cell culture supernatant, i.e. conditioned media (CM). The cells were isolated and characterized from umbilical tissue off-cut. Excisional wound model was created in adult rats. In separate groups the bUC-MSCs and reconstituted lyophilized-CM were injected subcutaneously around the wound periphery at a regular interval for 3 weeks. Significant improvement (p < 0.05) in wound contraction percentage was noticed in bUC-MSC and CM groups as early as day 2. The histo-morphological analysis revealed that in bUC-MSC and CM-treated groups enhanced monocytoid cell migration was noticed in inflammatory phase, exhibited superior collagen organization, and wound remodeling, which are critical for minimizing scar formation and ensuring functional recovery of the skin. The sustained effects observed after four weeks suggest that both bUC-MSCs and CM not only accelerate early healing processes but also contribute to the structural integrity and durability of the healed tissue. Overall, bUC-MSCs and its conditioned media represent a valuable addition to the toolkit of regenerative medicine.
期刊介绍：
Regenerative medicine replaces or regenerates human cells, tissue or organs, to restore or establish normal function*. Since 2006, Regenerative Medicine has been at the forefront of publishing the very best papers and reviews covering the entire regenerative medicine sector. The journal focusses on the entire spectrum of approaches to regenerative medicine, including small molecule drugs, biologics, biomaterials and tissue engineering, and cell and gene therapies – it’s all about regeneration and not a specific platform technology. The journal’s scope encompasses all aspects of the sector ranging from discovery research, through to clinical development, through to commercialization. Regenerative Medicine uniquely supports this important area of biomedical science and healthcare by providing a peer-reviewed journal totally committed to publishing the very best regenerative medicine research, clinical translation and commercialization.
Regenerative Medicine provides a specialist forum to address the important challenges and advances in regenerative medicine, delivering this essential information in concise, clear and attractive article formats – vital to a rapidly growing, multidisciplinary and increasingly time-constrained community.
Despite substantial developments in our knowledge and understanding of regeneration, the field is still in its infancy. However, progress is accelerating. The next few decades will see the discovery and development of transformative therapies for patients, and in some cases, even cures. Regenerative Medicine will continue to provide a critical overview of these advances as they progress, undergo clinical trials, and eventually become mainstream medicine.
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