Revival of neurophysin-I as a complementary biomarker for circulating oxytocin.

IF 3.8 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Pituitary Pub Date : 2026-08-20 DOI:10.1007/s11102-026-01745-y

Elizabeth A Lawson

引用次数: 0

Abstract

There is renewed interest in oxytocin (OXT) associated neurophysin-I (NP-I) as a surrogate biomarker of endogenous OXT secretion into circulation. OXT measurement in humans remains challenging because current assays vary in their specificity for free and protein-bound OXT, and OXT-related peptide species, including extended forms and peptide fragments, and results are influenced by sample handling and analytical methods. NP-I, a carrier protein that is co-synthesized and co-secreted with OXT, can be measured using a validated sandwich immunoassay without extraction. Studies support NP-I as a promising marker of OXT release to circulation, although it is not a replacement for direct OXT measurement. This Editorial reviews the biological relationship between OXT and NP-I, discusses the advantages and limitations of NP-I as a biomarker, and highlights future opportunities for integrating NP-I measurement with advances in OXT assay methodology to improve understanding of the human OXT system in health and disease.

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神经素- 1作为循环催产素的补充生物标志物的复兴。

人们对催产素（OXT）相关的神经physin- i （NP-I）作为内源性OXT分泌进入循环的替代生物标志物重新产生了兴趣。人体OXT的测量仍然具有挑战性，因为目前的检测方法对游离OXT和蛋白结合OXT以及OXT相关肽种（包括扩展形式和肽片段）的特异性各不相同，而且结果受样品处理和分析方法的影响。NP-I是一种与OXT共同合成和共同分泌的载体蛋白，可以使用经过验证的三明治免疫分析法进行测量，而无需提取。研究支持np - 1作为OXT释放到血液循环的有希望的标记物，尽管它不能替代直接OXT测量。这篇社论回顾了OXT和NP-I之间的生物学关系，讨论了NP-I作为生物标志物的优势和局限性，并强调了将NP-I测量与OXT测定方法的进展相结合的未来机会，以提高对人类健康和疾病中OXT系统的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pituitary 医学-内分泌学与代谢

CiteScore

7.10

自引率

7.90%

发文量

审稿时长

6 months

期刊介绍： Pituitary is an international publication devoted to basic and clinical aspects of the pituitary gland. It is designed to publish original, high quality research in both basic and pituitary function as well as clinical pituitary disease. The journal considers: Biology of Pituitary Tumors Mechanisms of Pituitary Hormone Secretion Regulation of Pituitary Function Prospective Clinical Studies of Pituitary Disease Critical Basic and Clinical Reviews Pituitary is directed at basic investigators, physiologists, clinical adult and pediatric endocrinologists, neurosurgeons and reproductive endocrinologists interested in the broad field of the pituitary and its disorders. The Editorial Board has been drawn from international experts in basic and clinical endocrinology. The journal offers a rapid turnaround time for review of manuscripts, and the high standard of the journal is maintained by a selective peer-review process which aims to publish only the highest quality manuscripts. Pituitary will foster the publication of creative scholarship as it pertains to the pituitary and will provide a forum for basic scientists and clinicians to publish their high quality pituitary-related work.