Seawater drowning induced acute lung injury: new insights from novel mouse models and micro-CT imaging.

IF 1.8 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine Pub Date : 2026-08-24 eCollection Date: 2026-01-01 DOI:10.1515/med-2026-1510

Jinxia Liu, Chunsun Li, Zhen Yang, Yuanhui Wei, Zhixin Liang, Xiuqing Ma, Shangshu Liu, Jiabo Ren, Zhenfei Mo, Yue Yin, Zirui Wang, Liangan Chen

{"title":"Seawater drowning induced acute lung injury: new insights from novel mouse models and micro-CT imaging.","authors":"Jinxia Liu, Chunsun Li, Zhen Yang, Yuanhui Wei, Zhixin Liang, Xiuqing Ma, Shangshu Liu, Jiabo Ren, Zhenfei Mo, Yue Yin, Zirui Wang, Liangan Chen","doi":"10.1515/med-2026-1510","DOIUrl":null,"url":null,"abstract":"Objectives: Seawater drowning causes severe lung and alveolar damage, easily inducing acute respiratory distress syndrome with high early mortality. Currently, standardized assessment and treatment approaches for seawater drowning-induced acute lung injury (SWD-ALI) are lacking. This study aimed to explore the lung damage mechanism of seawater drowning and provide early diagnostic and clinical therapeutic references for SWD-ALI.Methods: A novel mouse model of SWD-ALI was established for the first time via the laryngoscopic endotracheal injection (LEI) method. Multiple indicators including lung histopathology, survival rate, bronchoalveolar lavage fluid, lung coefficient and micro-CT were detected in strict accordance with the latest animal acute lung injury testing standards.Results: Obvious exudative lesions in lung tissues were detected by CT as early as 0.5 h after seawater-induced injury, enabling early identification of severe acute lung injury.Conclusions: Lung CT can realize early diagnosis of SWD-ALI. This finding is critical for guiding clinical treatment and reducing the mortality of seawater drowning patients.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261510"},"PeriodicalIF":1.8000,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13499026/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1515/med-2026-1510","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: Seawater drowning causes severe lung and alveolar damage, easily inducing acute respiratory distress syndrome with high early mortality. Currently, standardized assessment and treatment approaches for seawater drowning-induced acute lung injury (SWD-ALI) are lacking. This study aimed to explore the lung damage mechanism of seawater drowning and provide early diagnostic and clinical therapeutic references for SWD-ALI.

Methods: A novel mouse model of SWD-ALI was established for the first time via the laryngoscopic endotracheal injection (LEI) method. Multiple indicators including lung histopathology, survival rate, bronchoalveolar lavage fluid, lung coefficient and micro-CT were detected in strict accordance with the latest animal acute lung injury testing standards.

Results: Obvious exudative lesions in lung tissues were detected by CT as early as 0.5 h after seawater-induced injury, enabling early identification of severe acute lung injury.

Conclusions: Lung CT can realize early diagnosis of SWD-ALI. This finding is critical for guiding clinical treatment and reducing the mortality of seawater drowning patients.

查看原文本刊更多论文

海水溺水引起的急性肺损伤：来自新型小鼠模型和微ct成像的新见解。

目的：海水溺水造成严重的肺和肺泡损伤，易诱发急性呼吸窘迫综合征，早期死亡率高。目前，海水溺水致急性肺损伤（SWD-ALI）缺乏标准化的评估和治疗方法。本研究旨在探讨海水溺水肺损伤机制，为SWD-ALI的早期诊断和临床治疗提供参考。方法：采用喉镜下气管内注射（LEI）方法，首次建立新型小鼠SWD-ALI模型。严格按照最新动物急性肺损伤检测标准检测肺组织病理学、存活率、支气管肺泡灌洗液、肺系数、显微ct等多项指标。结果：海水损伤后0.5 h CT可检出肺组织明显渗出性病变，可早期识别严重急性肺损伤。结论：肺部CT可实现SWD-ALI的早期诊断。这一发现对于指导临床治疗和降低海水溺水患者的死亡率具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Open Medicine Medicine-General Medicine

CiteScore

3.00

自引率

0.00%

发文量

153

审稿时长

20 weeks

期刊介绍： Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.