Timing of Malignant Transformation in Recurrent Versus Nonrecurrent Oral Potentially Malignant Disorders: A Retrospective Study.

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2026-08-20 DOI:10.1111/odi.70477

Shih-Wei Yang, Yi-Chan Lee, Yun-Shien Lee

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引用次数: 0

Abstract

Objective: Postoperative recurrence of oral potentially malignant disorders (OPMDs) is common. This study investigated whether the timing of malignant transformation differs between recurrent and nonrecurrent lesions.

Methods: This retrospective observational study included patients who underwent carbon dioxide laser excision for OPMDs and later developed oral squamous cell carcinoma between July 2002 and July 2024. Clinicopathological characteristics and transformation intervals were compared between recurrent and nonrecurrent lesions.

Results: Among 898 treated patients, 38 (4.2%) developed malignant transformation. Of these, 28 (73.7%) had no postoperative recurrence before malignant transformation, whereas 10 (26.3%) experienced recurrence. Although most malignant transformation cases occurred in nonrecurrent lesions, recurrent lesions had a significantly shorter transformation interval (p = 0.014). All recurrent lesions progressed to oral squamous cell carcinoma within 2.3 years, whereas nonrecurrent lesions exhibited a broader range of transformation intervals, extending from several weeks to more than 13 years. No significant differences were observed in other clinicopathological characteristics.

Conclusions: Although most malignant transformation cases occurred in OPMDs without documented postoperative recurrence, recurrent OPMDs were associated with a significantly shorter transformation interval. These findings suggest that recurrent lesions may warrant closer clinical surveillance, while long-term surveillance remains important regardless of recurrence status.

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复发性与非复发性口腔潜在恶性疾病的恶性转化时机：一项回顾性研究。

目的：口腔潜在恶性疾病（OPMDs）术后复发是常见的。本研究调查了复发性和非复发性病变的恶性转化时间是否不同。方法：本回顾性观察研究纳入了2002年7月至2024年7月期间接受二氧化碳激光切除OPMDs并随后发展为口腔鳞状细胞癌的患者。比较复发性和非复发性病变的临床病理特征和转化时间。结果：898例患者中，38例（4.2%）发生恶性转化。其中28例（73.7%）在恶性转化前无术后复发，10例（26.3%）复发。虽然大多数恶性转化发生在非复发性病灶，但复发性病灶的恶性转化间隔明显较短（p = 0.014）。所有复发性病变都在2.3年内进展为口腔鳞状细胞癌，而非复发性病变的转化间隔范围更广，从几周到13年以上。其他临床病理特征差异无统计学意义。结论：虽然大多数恶性转化病例发生在OPMDs中，术后无复发记录，但复发的OPMDs与明显较短的转化间隔相关。这些发现表明，复发性病变可能需要更密切的临床监测，而长期监测仍然重要，无论复发状态如何。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.