Salivary Apelin Levels and Periodontal Findings in Individuals With/Without Type 1 Diabetes and Varying Degrees of Gingival Inflammation.

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2026-08-20 DOI:10.1111/odi.70467

Demet Efe Yavaşoğlu, Andressa V B Nogueira, Mehmet Demirbaş, Timur Köse, Sebahat Kaya, James Deschner, Nurcan Buduneli

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引用次数: 0

Abstract

Objective: To evaluate salivary apelin levels in individuals with and without type 1 diabetes presenting an intact periodontium and varying degrees of plaque-induced gingival inflammation.

Methods: Saliva samples were collected; and whole-mouth clinical periodontal measurements were recorded in type 1 diabetes and systemically healthy participants. Salivary apelin concentrations were determined using ELISA. Data were analysed statistically using the Shapiro-Wilk test for normality of distribution, the Mann-Whitney U test for intergroup differences, and Spearman's rank correlation analysis to assess correlations between clinical and biochemical parameters.

Results: A total of 99 participants; including 59 individuals in the type 1 diabetes group and 40 in the systemically healthy were included. The two groups were similar in terms of age, gender distribution, and smoking status (p > 0.05). The salivary apelin concentration in the diabetic group (4647.13 ± 8584.45 pg/mL) was almost twice that in the systemically healthy group (2704.12 ± 3006.73 pg/mL) without statistically significant difference (0.114). Clinical periodontal measurements were similar between the two groups (p > 0.05). Neither gender nor smoking status had a significant effect on apelin levels (p > 0.05).

Conclusions: Within the limitations of this study, the observed trend toward higher salivary apelin levels in patients with type 1 diabetes may suggest a possible association that requires confirmation in larger cohorts.

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有/没有1型糖尿病和不同程度牙龈炎症的个体唾液Apelin水平和牙周表现

目的：评估1型糖尿病患者和非1型糖尿病患者牙周组织完整和不同程度的牙菌斑引起的牙龈炎症的唾液尖蛋白水平。方法：采集唾液样本；并记录了1型糖尿病和系统健康参与者的全口临床牙周测量。采用ELISA法测定唾液apelin浓度。采用Shapiro-Wilk检验检验分布正态性，Mann-Whitney U检验组间差异，Spearman秩相关分析评价临床与生化参数的相关性。结果：共99名受试者；包括59名1型糖尿病患者和40名全身性健康人。两组患者在年龄、性别分布、吸烟状况等方面差异无统计学意义（p < 0.05）。糖尿病组唾液apelin浓度（4647.13±8584.45 pg/mL）几乎是健康组（2704.12±3006.73 pg/mL）的2倍，差异无统计学意义（0.114）。两组临床牙周测量值比较，差异无统计学意义（p < 0.05）。性别和吸烟状况对apelin水平均无显著影响（p < 0.05）。结论：在本研究的局限性内，观察到的1型糖尿病患者唾液尖蛋白水平升高的趋势可能表明一种可能的关联，需要在更大的队列中得到证实。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.