Clinical Relevance of Lymphovascular and Perineural Invasion in Oral Squamous Cell Carcinoma: Emphasis on Pathological N1 Cases.

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2026-08-18 DOI:10.1111/odi.70472

Juan Carlos de Vicente, Álvaro Fernández Del Valle, Tania Rodríguez Santamarta, Ignacio Peña, Lucas Villalaín Álvarez, Sergi Herrera I Nogués, Ana Martínez-Carrillo, Miriam Rubiera-Valdés, Paloma Lequerica-Fernández

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引用次数: 0

Abstract

Objective: This study aimed to investigate the clinical relevance of lymphovascular invasion (LVI) and perineural invasion (PNI) in oral squamous cell carcinoma (OSCC).

Methods: We conducted a retrospective study of 181 OSCC patients, analyzing clinical outcomes in terms of disease-specific survival (DSS) and disease-free survival (DFS).

Results: In multivariate analysis, T classification, LVI, and PNI were independent predictors of nodal metastasis, while nodal metastasis and extranodal extension were independent predictors of DSS, and T classification and nodal status were independent predictors of DFS. In N1 cases, LVI was significantly associated with poorer DSS and DFS. Survival was also significantly worse in double-positive patients (LVI and PNI) compared with double-negative or single-positive cases.

Conclusion: The presence of LVI and/or PNI is an independent risk factor for node metastasis, even when accounting for other factors such as DOI. N1 tumors with LVI show significantly poorer DSS and DFS, regardless of extranodal extension.

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口腔鳞状细胞癌淋巴血管及周围神经浸润的临床意义：以病理N1病例为重点。

目的：探讨口腔鳞状细胞癌（OSCC）淋巴血管浸润（LVI）和神经周围浸润（PNI）的临床意义。方法：我们对181例OSCC患者进行回顾性研究，分析疾病特异性生存（DSS）和无病生存（DFS）的临床结果。结果：在多因素分析中，T分型、LVI和PNI是淋巴结转移的独立预测因子，而淋巴结转移和结外延伸是DSS的独立预测因子，T分型和淋巴结状态是DFS的独立预测因子。在N1例中，LVI与较差的DSS和DFS显著相关。与双阴性或单阳性病例相比，双阳性患者（LVI和PNI）的生存率也明显更差。结论：即使考虑到DOI等其他因素，LVI和/或PNI的存在也是淋巴结转移的独立危险因素。与淋巴结外延伸无关，LVI的N1肿瘤的DSS和DFS明显较差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.