Protective effect and mechanism of SIRT1 under stress-induced vascular senescence.

Abstract

A major focus of contemporary medical research is the primary pathological cardiovascular diseases, whereas stress-induced vascular senescence is a process with degenerative changes in vascular morphology, structure, and function caused by oxidative stress (OS), inflammation, autophagy disorders, and other factors. Silent information regulator of transcription 1 (SIRT1), which may be a key gene linking oxidative stress and aging, has extensive biological functions in anti-oxidation, anti-inflammation, anti-apoptosis, and other aspects. This paper focuses on the protective effects and main mechanisms of SIRT1 on stress-induced vascular senescence and provides clues for preventing and treating diseases related to stress-induced vascular senescence.