Effect of Vitamin D3 Supplementation on Sleep Quality in Deficient Adults: A Randomized Controlled Trial.

IF 0.8 3区医学 Q4 NEUROSCIENCES

Neurology India Pub Date : 2026-08-19 DOI:10.4103/neurol-india.Neurol-India-D-26-00162

Lakshmi Priya Lalitha, Pradeep Rangaiah, Anish Mehta, Mahendra Javali, Purushottam T Acharya, Shivaraj Nallur Somanna

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引用次数: 0

Abstract

Background: Emerging evidence suggests a link between serum vitamin D3 deficiency and poor sleep quality, but the optimal dosing frequency to improve sleep quality remains unclear. This study investigates the impact of daily versus weekly vitamin D3 supplementation on sleep quality in adults with vitamin D3 deficiency.

Methods: This single-center, prospective, single-blinded, randomized controlled trial randomized vitamin D3-deficient adults in a 1:1 ratio to receive either daily supplementation (6000 IU/day for 8 weeks) or weekly supplementation (60,000 IU/week for 8 weeks). Subjective sleep quality was evaluated with the Pittsburg Sleep Quality Index (PSQI) questionnaire at baseline and after 8 weeks. The Wilcoxon signed-rank test and Mann-Whitney U test were used to compare both groups.

Results: This study enrolled 87 patients, with 45 in the weekly arm and 42 in the daily arm. The mean age was 39.26 [11.03] years, and 71% (n = 62) were female. On follow-up, the daily arm showed significant improvements in "duration of sleep" (0.93 [0.65] vs 1.55 [0.75], P = 0.002) and "daytime dysfunction due to sleep" (0.67 [0.57] vs 1.11 [1.15], P = 0.007). In contrast, the weekly arm performed better in the "need medication to sleep" parameter (0.13 [0.50] vs 0.37 [0.54], P = 0.034). However, the daily supplementation arm showed a favorable trend in the PSQI total score (8.46 [3.14] vs 9.93 [2.68], P = 0.024).

Conclusion: Daily vitamin D3 supplementation is more effective than weekly supplementation in improving overall sleep quality, sleep duration, and daytime dysfunction in vitamin D3-deficient adults.

Trial registration: Clinical Trial Registry of India (CTRI/2024/01/061970) on 29.1.2024.

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维生素D3补充对睡眠不足成人睡眠质量的影响：一项随机对照试验。

背景：新出现的证据表明血清维生素D3缺乏与睡眠质量差之间存在联系，但改善睡眠质量的最佳剂量频率仍不清楚。这项研究调查了每天和每周补充维生素D3对维生素D3缺乏症成年人睡眠质量的影响。方法：这项单中心、前瞻性、单盲、随机对照试验将维生素d3缺乏的成年人按1:1的比例随机分配，每天补充（6000 IU/天，持续8周）或每周补充（60,000 IU/周，持续8周）。采用匹兹堡睡眠质量指数（PSQI）对受试者进行主观睡眠质量评价。采用Wilcoxon sign -rank检验和Mann-Whitney U检验对两组进行比较。结果：本研究纳入87例患者，其中45例为每周治疗组，42例为每日治疗组。平均年龄39.26[11.03]岁，女性占71% （n = 62）。在随访中，每日组在“睡眠持续时间”（0.93 [0.65]vs 1.55 [0.75], P = 0.002）和“睡眠引起的日间功能障碍”（0.67 [0.57]vs 1.11 [1.15], P = 0.007）方面均有显著改善。相比之下，每周组在“需要药物入睡”参数上表现更好（0.13 [0.50]vs 0.37 [0.54], P = 0.034）。然而，每日补充组在PSQI总分方面表现出有利的趋势（8.46 [3.14]vs 9.93 [2.68], P = 0.024）。结论：每天补充维生素D3比每周补充维生素D3在改善维生素D3缺乏症成年人的整体睡眠质量、睡眠时间和白天功能障碍方面更有效。试验注册：印度临床试验注册中心（CTRI/2024/01/061970）于2024年1月29日注册。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurology India 医学-神经科学

CiteScore

1.60

自引率

70.40%

发文量

434

审稿时长

2 months

期刊介绍： Neurology India (ISSN 0028-3886) is Bi-monthly publication of Neurological Society of India. Neurology India, the show window of the progress of Neurological Sciences in India, has successfully completed 50 years of publication in the year 2002. ‘Neurology India’, along with the Neurological Society of India, has grown stronger with the passing of every year. The full articles of the journal are now available on internet with more than 20000 visitors in a month and the journal is indexed in MEDLINE and Index Medicus, Current Contents, Neuroscience Citation Index and EMBASE in addition to 10 other indexing avenues. This specialty journal reaches to about 2000 neurologists, neurosurgeons, neuro-psychiatrists, and others working in the fields of neurology.