Epigenetic changes linked to cell replication connect ageing with cancer risk

IF 60.7 1区医学 Q1 ONCOLOGY

Nature Reviews Cancer Pub Date : 2026-08-19 DOI:10.1038/s41568-026-00972-6

Sandra Romero-Cordoba

引用次数: 0

Abstract

In this Journal Club, Sandra Romero-Cordoba discusses a study that identifies a replication-associated DNA methylation signature, termed CellDRIFT, providing evidence that epigenetic drift linked to cell division may contribute to oncogenic transformation.

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与细胞复制相关的表观遗传变化将衰老与癌症风险联系起来。

在这篇Journal Club中，Sandra Romero-Cordoba讨论了一项研究，该研究确定了与复制相关的DNA甲基化特征，称为CellDRIFT，这为与细胞分裂相关的表观遗传漂变可能有助于致癌转化提供了证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Cancer 医学-肿瘤学

CiteScore

111.90

自引率

0.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cancer, a part of the Nature Reviews portfolio of journals, aims to be the premier source of reviews and commentaries for the scientific communities it serves. The correct abbreviation for abstracting and indexing purposes is Nat. Rev. Cancer. The international standard serial numbers (ISSN) for Nature Reviews Cancer are 1474-175X (print) and 1474-1768 (online). Unlike other journals, Nature Reviews Cancer does not have an external editorial board. Instead, all editorial decisions are made by a team of full-time professional editors who are PhD-level scientists. The journal publishes Research Highlights, Comments, Reviews, and Perspectives relevant to cancer researchers, ensuring that the articles reach the widest possible audience due to their broad scope.