RNA-binding protein guides polymerase recruitment during gene activation

IF 25.5 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2026-08-19 DOI:10.1038/s41588-026-02711-x

引用次数: 0

Abstract

Enhancers activate genes through long-range chromatin looping, but how these regulatory elements communicate with gene promoters and trigger transcription has remained unclear. We show that the RNA-binding protein hnRNPK acts as a molecular bridge that connects enhancer–promoter communication with recruitment of RNA polymerase II.

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rna结合蛋白在基因激活过程中引导聚合酶募集。

增强子通过长链染色质环激活基因，但这些调控元件如何与基因启动子沟通并触发转录仍不清楚。我们发现RNA结合蛋白hnRNPK作为连接增强子-启动子通信与RNA聚合酶II募集的分子桥梁。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution