Lipid metabolic reprogramming in ovarian cancer: molecular mechanisms and therapeutic implications.

IF 1.4 4区医学 Q3 PATHOLOGY

Medical Molecular Morphology Pub Date : 2026-08-23 DOI:10.1007/s00795-026-00469-z

Naomi Nakayama, Daisaku Asai, Tomoka Ishibashi, Tsubasa Maejima, Kentaro Nakayama

引用次数: 0

Abstract

Lipids play diverse roles in cellular homeostasis, and dysregulation of lipid metabolism is implicated in a wide spectrum of diseases, including cancer. Ovarian cancer cells exhibit profound metabolic alterations that support autonomous proliferation under conditions of hypoxia and nutrient limitation. Although tumor angiogenesis occurs, insufficient and fragile neovasculature often limits nutrient supply, necessitating metabolic adaptation. Among these adaptations, lipid metabolic reprogramming has emerged as a critical feature that supports tumor growth, survival, invasion, and therapeutic resistance. Alterations in fatty acid synthesis, β-oxidation, lipid uptake, and inflammatory lipid metabolism collectively contribute to the malignant phenotype. This review summarizes current knowledge of lipid metabolic regulation in ovarian cancer, with particular emphasis on key enzymes and their regulatory mechanism and discusses potential implications for therapeutic targeting from a molecular and morphological perspective.

查看原文本刊更多论文

卵巢癌的脂质代谢重编程：分子机制和治疗意义。

脂质在细胞内稳态中起着多种作用，脂质代谢失调与包括癌症在内的多种疾病有关。卵巢癌细胞表现出深刻的代谢改变，在缺氧和营养限制的条件下支持自主增殖。虽然肿瘤发生血管生成，但新生血管的不足和脆弱往往限制了营养供应，需要代谢适应。在这些适应中，脂质代谢重编程已成为支持肿瘤生长、存活、侵袭和治疗抵抗的关键特征。脂肪酸合成、β-氧化、脂质摄取和炎症性脂质代谢的改变共同导致了恶性表型。本文综述了目前关于卵巢癌脂质代谢调控的知识，重点介绍了关键酶及其调控机制，并从分子和形态学角度讨论了治疗靶向的潜在意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Medical Molecular Morphology 医学-病理学

CiteScore

2.90

自引率

5.60%

发文量

审稿时长

>12 weeks

期刊介绍： Medical Molecular Morphology is an international forum for researchers in both basic and clinical medicine to present and discuss new research on the structural mechanisms and the processes of health and disease at the molecular level. The structures of molecules, organelles, cells, tissues, and organs determine their normal function. Disease is thus best understood in terms of structural changes in these different levels of biological organization, especially in molecules and molecular interactions as well as the cellular localization of chemical components. Medical Molecular Morphology welcomes articles on basic or clinical research in the fields of cell biology, molecular biology, and medical, veterinary, and dental sciences using techniques for structural research such as electron microscopy, confocal laser scanning microscopy, enzyme histochemistry, immunohistochemistry, radioautography, X-ray microanalysis, and in situ hybridization. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.