Salivary flow and oral health-related quality of life in edentulous denture stomatitis positive individuals: A randomized clinical trial

IF 5.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Prosthetic Dentistry Pub Date : 2026-10-01 Epub Date: 2026-08-20 DOI:10.1016/j.prosdent.2026.07.031

Adriana Barbosa Ribeiro DDS, PhD, Lorena Mosconi Clemente DDS, MSc, Beatriz de Camargo Poker DDS, MSc, Júlio Cesar Taffarel DDS, Vinícius Sabedra DDS, Ana Paula Macedo PhD, Helio Cesar Salgado PhD, Cláudia Helena Silva-Lovato DDS, PhD

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引用次数: 0

Abstract

Statement of problem

The effects of different denture stomatitis (DS) management strategies on oral health-related quality of life (OHRQoL) and salivary flow (SF) in complete denture wearers remain unclear.

Purpose

The purpose of this double-blind, parallel-group randomized clinical trial was to compare the effects of nystatin therapy and sodium hypochlorite denture hygiene on OHRQoL, salivary flow (SF), and DS severity in complete denture wearers.

Material and methods

A total of 50 complete denture wearers with DS were allocated to 2 groups: nystatin mouth rinse (GN) or a sodium hypochlorite (GSH0.25%)-based denture hygiene protocol. OHRQoL, SF, and DS severity were assessed at baseline and at 15 and 45 days, and data were analyzed using generalized estimating equations (α=.05).

Results

Forty-seven participants completed the study. Significant improvements over time were observed in OHRQoL overall and domains related to masticatory function, social disability, and psychological discomfort (P≤.001), regardless of treatment, with no treatment-by-time interactions. SF remained stable over time, with no significant effects of treatment, time, or interaction (P>.05). DS severity decreased significantly over time (P<.001), with no significant differences between groups or interaction effects (P>.05).

Conclusions

Both therapies were associated with improved OHRQoL in complete denture wearers with DS. These improvements occurred alongside reductions in denture stomatitis severity, while salivary flow remained stable, suggesting a multifactorial process involving clinical and behavioral factors.

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无牙义齿口炎阳性个体的唾液流和口腔健康相关生活质量：一项随机临床试验

问题陈述：不同的义齿口炎（DS）管理策略对全口义齿佩戴者口腔健康相关生活质量（OHRQoL）和唾液流量（SF）的影响尚不清楚。目的：本双盲、平行组随机临床试验的目的是比较制霉素治疗和次氯酸钠义齿卫生对全口义齿佩戴者OHRQoL、唾液流量（SF）和DS严重程度的影响。材料和方法：将50例患有DS的全口义齿佩戴者分为两组：制霉菌素漱口水组（GN）和次氯酸钠（GSH0.25%）为基础的义齿卫生方案。在基线、15天和45天评估OHRQoL、SF和DS严重程度，并使用广义估计方程分析数据（α= 0.05）。结果：47名参与者完成了研究。随着时间的推移，观察到总体的OHRQoL以及与咀嚼功能、社交障碍和心理不适相关的领域（P≤0.001）显著改善，无论治疗方式如何，没有治疗时间的相互作用。随着时间的推移，SF保持稳定，治疗、时间或相互作用没有显著影响（P < 0.05）。随着时间的推移，退行性椎体滑移的严重程度显著降低（p < 0.05）。结论：两种治疗方法均可改善退行性痴呆患者的OHRQoL。这些改善发生在假牙口炎严重程度降低的同时，而唾液流量保持稳定，这表明一个涉及临床和行为因素的多因素过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Prosthetic Dentistry 医学-牙科与口腔外科

CiteScore

7.00

自引率

13.00%

发文量

599

审稿时长

69 days

期刊介绍： The Journal of Prosthetic Dentistry is the leading professional journal devoted exclusively to prosthetic and restorative dentistry. The Journal is the official publication for 24 leading U.S. international prosthodontic organizations. The monthly publication features timely, original peer-reviewed articles on the newest techniques, dental materials, and research findings. The Journal serves prosthodontists and dentists in advanced practice, and features color photos that illustrate many step-by-step procedures. The Journal of Prosthetic Dentistry is included in Index Medicus and CINAHL.