Weighted and unweighted comorbidity burden for predicting three-year neurodevelopment in extremely preterm infants: A nationwide cohort study.

IF 2.3 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2026-08-21 DOI:10.1038/s41372-026-02873-w

Shuji Ishida, Hidehiko Nakanishi, Izumi Iitsuka, Moe Matsuura, Yoshie Oosaki, Maki Iwai, Rika Sekiya, Kohei Kawada, Yukako Kosaka, Ayano Yamaguchi, Mari Ooka

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引用次数: 0

Abstract

Objective: To compare the prognostic utility of unweighted morbidity counts and weighted morbidity scores for predicting neurodevelopmental outcomes at 3 years in extremely preterm infants.

Study design: This retrospective cohort study used data from the Neonatal Research Network of Japan and included infants born at <28 weeks' gestation. Neurodevelopment at 3 years was assessed using developmental quotient and cerebral palsy. Cumulative morbidity burden was quantified using unweighted morbidity counts and weighted morbidity scores derived from log-odds ratios for severe impairment. Inverse probability weighting addressed incomplete follow-up.

Results: Both unweighted morbidity counts and weighted morbidity scores were significantly associated with adverse neurodevelopmental outcomes. Unweighted morbidity counts demonstrated higher sensitivity for identifying any adverse outcome, whereas weighted morbidity scores showed high specificity (0.94) for severe impairment.

Conclusion: Unweighted morbidity counts and weighted morbidity scores provide complementary prognostic information and may improve risk stratification, follow-up prioritization, and family counseling for extremely preterm infants.

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预测极早产儿3岁神经发育的加权和未加权共病负担：一项全国性队列研究。

目的：比较未加权发病率计数和加权发病率评分在预测3岁极早产儿神经发育结局方面的预后效用。研究设计：这项回顾性队列研究使用了来自日本新生儿研究网络的数据，包括在以下时间出生的婴儿：结果：未加权发病率计数和加权发病率评分与不良神经发育结局显著相关。未加权的发病率计数显示出识别任何不良结果的更高敏感性，而加权发病率评分显示出严重损害的高特异性（0.94）。结论：未加权发病率计数和加权发病率评分提供了补充的预后信息，并可能改善极早产儿的风险分层、随访优先级和家庭咨询。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.