The impact of metabolic syndrome on changes in trunk muscle CSA: a 10-year longitudinal study.

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Journal of Bone and Mineral Metabolism Pub Date : 2026-08-22 DOI:10.1007/s00774-026-01750-y

Yosuke Mano, Eiichiro Nakamura, Manabu Tsukamoto, Takayuki Nabeshima, Toru Nakagawa, Yoichi Murata, Masaru Takeda, Kenichiro Narusawa, Kenji Shimizu, Yoshiaki Yamanaka, Hitoshi Suzuki, Soshi Uchida, Takeshi Hayashi, Akinori Sakai

{"title":"The impact of metabolic syndrome on changes in trunk muscle CSA: a 10-year longitudinal study.","authors":"Yosuke Mano, Eiichiro Nakamura, Manabu Tsukamoto, Takayuki Nabeshima, Toru Nakagawa, Yoichi Murata, Masaru Takeda, Kenichiro Narusawa, Kenji Shimizu, Yoshiaki Yamanaka, Hitoshi Suzuki, Soshi Uchida, Takeshi Hayashi, Akinori Sakai","doi":"10.1007/s00774-026-01750-y","DOIUrl":null,"url":null,"abstract":"Introduction: Few studies have investigated the relationship between metabolic syndrome (MetS) and muscle loss over a 10-year period in large working populations. This study aimed to investigate the influence of MetS-related and respiratory factors on changes in trunk muscles in the working population.Materials and methods: The cross-sectional areas (CSAs) of the psoas major (PM) and erector spinae (ES) were measured using abdominal low-dose CT imaging at baseline and at 10 years. Predictors of CSA loss were analyzed using multiple linear regression analysis.Results: A total of 1504 males were included. The change in the CSA of the PM at 10 years decreased significantly with increasing age, BMI, abdominal circumference, visceral fat area (VFA), systolic blood pressure (sBP), and HbA1c. The change in the CSA of the ES at 10 years decreased significantly with increasing age, weight, BMI, abdominal circumference, VFA, sBP, HbA1c, and LDL level. Multiple linear regression analysis revealed that VFA and HbA1c were independently associated with PM loss, while a lower percentage vital capacity (%VC) was associated with ES loss. The ratio of forced expiratory volume in one second to forced vital capacity (FEV1.0%) at baseline was identified as a significant predictor of PM loss for individuals with MetS.Conclusion: Among MetS-related factors, VFA and HbA1c were associated with trunk muscle CSA loss over 10 years in the working population. Furthermore, in individuals with MetS, lower FEV1.0% was associated with PM loss.","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Bone and Mineral Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00774-026-01750-y","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Few studies have investigated the relationship between metabolic syndrome (MetS) and muscle loss over a 10-year period in large working populations. This study aimed to investigate the influence of MetS-related and respiratory factors on changes in trunk muscles in the working population.

Materials and methods: The cross-sectional areas (CSAs) of the psoas major (PM) and erector spinae (ES) were measured using abdominal low-dose CT imaging at baseline and at 10 years. Predictors of CSA loss were analyzed using multiple linear regression analysis.

Results: A total of 1504 males were included. The change in the CSA of the PM at 10 years decreased significantly with increasing age, BMI, abdominal circumference, visceral fat area (VFA), systolic blood pressure (sBP), and HbA1c. The change in the CSA of the ES at 10 years decreased significantly with increasing age, weight, BMI, abdominal circumference, VFA, sBP, HbA1c, and LDL level. Multiple linear regression analysis revealed that VFA and HbA1c were independently associated with PM loss, while a lower percentage vital capacity (%VC) was associated with ES loss. The ratio of forced expiratory volume in one second to forced vital capacity (FEV1.0%) at baseline was identified as a significant predictor of PM loss for individuals with MetS.

Conclusion: Among MetS-related factors, VFA and HbA1c were associated with trunk muscle CSA loss over 10 years in the working population. Furthermore, in individuals with MetS, lower FEV1.0% was associated with PM loss.

查看原文本刊更多论文

代谢综合征对躯干肌CSA变化的影响：一项10年的纵向研究。

在过去的10年里，很少有研究调查了大量工作人群中代谢综合征（MetS）和肌肉损失之间的关系。本研究旨在探讨mets相关因素和呼吸因素对劳动人群躯干肌肉变化的影响。材料和方法：在基线和10年时使用腹部低剂量CT成像测量腰大肌（PM）和竖脊肌（ES）的横截面积（csa）。采用多元线性回归分析CSA损失的预测因素。结果：共纳入1504名男性。PM 10年时CSA的变化随着年龄、BMI、腹围、内脏脂肪面积（VFA）、收缩压（sBP）和HbA1c的增加而显著降低。随着年龄、体重、BMI、腹围、VFA、sBP、HbA1c和LDL水平的增加，ES 10年CSA的变化显著降低。多元线性回归分析显示，VFA和HbA1c与PM损失独立相关，而较低的肺活量百分比（%VC）与ES损失相关。一秒钟用力呼气量与基线时用力肺活量（FEV1.0%）之比被确定为MetS患者PM损失的重要预测因子。结论：在met相关因素中，VFA和HbA1c与工作人群10年以上躯干肌CSA损失相关。此外，在met患者中，较低的FEV1.0%与PM损失相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Bone and Mineral Metabolism 医学-内分泌学与代谢

CiteScore

6.30

自引率

3.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Bone and Mineral Metabolism (JBMM) provides an international forum for researchers and clinicians to present and discuss topics relevant to bone, teeth, and mineral metabolism, as well as joint and musculoskeletal disorders. The journal welcomes the submission of manuscripts from any country. Membership in the society is not a prerequisite for submission. Acceptance is based on the originality, significance, and validity of the material presented. The journal is aimed at researchers and clinicians dedicated to improvements in research, development, and patient-care in the fields of bone and mineral metabolism.