Aged rats have sex-dependent hypothermic effects but not spatial memory impairments following acute alcohol administration.

IF 3.4 3区医学 Q2 BEHAVIORAL SCIENCES

Frontiers in Behavioral Neuroscience Pub Date : 2026-08-03 eCollection Date: 2026-01-01 DOI:10.3389/fnbeh.2026.1904796

Douglas B Matthews, Megan Schroeder, Kennedy Korger, Olive Schrandt, Michael Tommarello, Katie Johnson, Ann Sobania, Pravesh Sharma

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Abstract

Introduction: The age of the world's population is continuing to increase, and older individuals are continuing to consume alcohol. Preclinical animal research has demonstrated that aged animals are significantly more sensitive to the effects of alcohol than younger animals and the effect of alcohol in aged animals is often sex dependent.

Methods: The current project investigates if acute alcohol administration produces sex dependent effects in hypothermia and spatial memory impairments in aged female and aged male Sprague Dawley rats.

Results: Acute alcohol administration produced sex dependent effects in that hypothermia in female rats was significantly greater following administration of 1.0 g/kg alcohol but not following 2.0 g/kg alcohol. However, spatial memory impairments were similar between aged female and aged male rats following a 1.0 g/kg alcohol challenge.

Discussion: The current results demonstrate in aged animals that alcohol administration produces sex dependent effects in some tasks and highlight the importance of determining the impact of alcohol in older adults as well as younger subjects.

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急性酒精给药后，老龄大鼠有性别依赖性的低温效应，但没有空间记忆障碍。

引言：世界人口的年龄在持续增长，老年人继续消费酒精。临床前动物研究表明，老年动物对酒精的影响明显比年轻动物更敏感，而且酒精对老年动物的影响往往是性别依赖的。方法：本项目研究急性酒精给药是否对老年雌性和雄性大鼠的低温和空间记忆障碍产生性别依赖效应。结果：急性酒精给药产生性别依赖效应，雌性大鼠在1.0 g/kg酒精给药后体温降低明显，而在2.0 g/kg酒精给药后体温降低不明显。然而，在1.0 g/kg酒精刺激下，老年雌性和老年雄性大鼠的空间记忆损伤相似。讨论：目前的结果表明，在老年动物中，酒精摄入在某些任务中产生性别依赖效应，并强调了确定酒精对老年人和年轻人的影响的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Behavioral Neuroscience BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

4.70

自引率

3.30%

发文量

506

审稿时长

6-12 weeks

期刊介绍： Frontiers in Behavioral Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the neural mechanisms underlying behavior. Field Chief Editor Nuno Sousa at the Instituto de Pesquisa em Ciências da Vida e da Saúde (ICVS) is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. This journal publishes major insights into the neural mechanisms of animal and human behavior, and welcomes articles studying the interplay between behavior and its neurobiological basis at all levels: from molecular biology and genetics, to morphological, biochemical, neurochemical, electrophysiological, neuroendocrine, pharmacological, and neuroimaging studies.