An acute crossover trial of passive movement training with and without blood flow restriction to determine the impact on postprandial glycaemia.

Abstract

During glucose uptake into muscle, GLUT-4 can translocate with stimulus from insulin or muscle contraction via exercise, but some exercise-intolerant populations are unable to benefit from improved glycaemic control. We investigated how passive movement training (PMT) and passive movement training with blood flow restriction (PMT+BFR) could be used as an alternative method. The effects on blood lactate and insulin were also investigated. Eleven healthy males (26.9 ± 8.3 years, 25.7 ± 2.1 kg/m²) undertook a crossover trial of three 150-min treatments, control (CTRL), PMT and PMT+BFR, on three separate study visits, separated by ≥24 h. Each participant arrived fasted and consumed a standardised high-carbohydrate meal (522 kcal, 112.5 g carbohydrate). The PMT protocol involved 30 min of intermittent bilateral knee extension/flexion (1 min:1 min work/rest) at an angular velocity of 180°/s through an 80° range of motion. PMT+BFR used a pressure calibrated at 80% arterial occlusion. Blood glucose and lactate were measured every 5 min, with insulin at 0, 30 and 60 min. Acute changes in muscle thickness were recorded using ultrasound pre- and post-intervention. There were no significant differences between the treatment groups for mean glucose (CTRL: 4.59 ± 0.48, PMT: 4.88 ± 0.82, PMT+BFR: 4.51 ± 0.90 mmol/L; P = 0.498). A statistically significant acute difference of muscle thickness (P = 0.00420) from pre- to post-treatment was detected in PMT+BFR. While PMT did not improve postprandial glycaemia with or without BFR, the acute increase in muscle thickness after PMT+BFR suggests that it may be useful in other applications.