Effect of Cannabinoids use on Symptoms of Restless Leg Syndrome among Adults: A Scoping Review.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Annals of Indian Academy of Neurology Pub Date : 2026-07-01 Epub Date: 2026-08-14 DOI:10.4103/aian.aian_1168_25

Sucheta Saha, Richa Tripathi, Lokesh Kumar Saini, Niraj Kumar, Ravi Gupta

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引用次数: 0

Abstract

Background and objectives: Restless leg syndrome (RLS) is a neurological disorder characterized by an irresistible urge to move the legs, often accompanied by unpleasant sensations such as tingling, crawling, or aching. Symptoms typically worsen during periods of rest or inactivity, particularly in the evening or at night. This scoping review aimed to synthesize the existing literature on the efficacy of cannabis and cannabinoids in alleviating symptoms associated with RLS.

Methods: A comprehensive search of electronic databases-including PubMed, Embase, Scopus, Cochrane Library, Google Scholar, ClinicalKey, and ClinicalTrials.gov-was conducted from database inception to April 30, 2025. Various keywords related to cannabis, cannabinoids, and RLS were used to identify relevant clinical studies.

Results: A total of 5,370 records were identified, of which seven studies met the inclusion criteria for final review. The evidence suggests that cannabis or cannabidiol may improve or prevent RLS symptoms.

Conclusions: Current evidence indicates that cannabis, in various forms, may alleviate or prevent symptoms of RLS through multiple mechanisms. However, the existing literature is limited to case reports, cross-sectional surveys, and post hoc analyses. In the absence of high-quality randomized controlled trials, the evidence is insufficient to support clinical recommendations at this time.

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大麻素对成人不宁腿综合征症状的影响：一项范围审查。

背景和目的：不宁腿综合征（RLS）是一种神经系统疾病，其特征是无法抗拒地移动腿部的冲动，通常伴有不愉快的感觉，如刺痛、爬行或疼痛。在休息或不活动期间，特别是在晚上或夜间，症状通常会恶化。本综述旨在综合现有关于大麻和大麻素在缓解RLS相关症状方面的疗效的文献。方法：全面检索PubMed、Embase、Scopus、Cochrane Library、谷歌Scholar、ClinicalKey、clinicaltrials .gov等电子数据库，从数据库建立到2025年4月30日。使用与大麻、大麻素、RLS相关的各种关键词来识别相关的临床研究。结果：共纳入5370条记录，其中7项研究符合最终审查的纳入标准。有证据表明，大麻或大麻二酚可以改善或预防睡眠倒睡症状。结论：目前的证据表明，各种形式的大麻可能通过多种机制缓解或预防RLS症状。然而，现有文献仅限于病例报告、横断面调查和事后分析。由于缺乏高质量的随机对照试验，目前的证据不足以支持临床推荐。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Indian Academy of Neurology Nervous System Diseases-

CiteScore

2.20

自引率

11.80%

发文量

293

审稿时长

29 weeks

期刊介绍： The journal has a clinical foundation and has been utilized most by clinical neurologists for improving the practice of neurology. While the focus is on neurology in India, the journal publishes manuscripts of high value from all parts of the world. Journal publishes reviews of various types, original articles, short communications, interesting images and case reports. The journal respects the scientific submission of its authors and believes in following an expeditious double-blind peer review process and endeavors to complete the review process within scheduled time frame. A significant effort from the author and the journal perhaps enables to strike an equilibrium to meet the professional expectations of the peers in the world of scientific publication. AIAN believes in safeguarding the privacy rights of human subjects. In order to comply with it, the journal instructs all authors when uploading the manuscript to also add the ethical clearance (human/animals)/ informed consent of subject in the manuscript. This applies to the study/case report that involves animal/human subjects/human specimens e.g. extracted tooth part/soft tissue for biopsy/in vitro analysis.