James J W Hucklesby, Charles P Unsworth, E Scott Graham, Catherine E Angel
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引用次数: 0
Abstract
Electrical impedance sensing offers a powerful, non-invasive method for real-time monitoring of cellular behaviour; with applications spanning immunology, cancer biology and drug discovery. Adoption of impedance-sensing approaches has been accelerated by the commercial availability of the ECIS, xCELLigence, ScioSpec and cellZscope platforms; however, the complexity and volume of impedance datasets produced has limited rigorous analysis. vascr, an open-source R-based toolkit designed to streamline the processing of impedance sensing datasets was created to facilitate rapid and simplified handling of cellular impedance sensing data. vascr can import multi-frequency data from multiple instrument manufacturers and includes robust analysis tools for resampling, outlier detection, and statistical testing using ANOVA and cross-correlation. Using the vascr workflow, impedance sensing data can be rapidly and robustly interpreted, allowing for real-time investigation of the effects of biological agents on cellular processes such as endothelial barrier integrity.
期刊介绍：
The journal publishes papers in the field of biophysics, which is defined as the study of biological phenomena by using physical methods and concepts. Original papers, reviews and Biophysics letters are published. The primary goal of this journal is to advance the understanding of biological structure and function by application of the principles of physical science, and by presenting the work in a biophysical context.
Papers employing a distinctively biophysical approach at all levels of biological organisation will be considered, as will both experimental and theoretical studies. The criteria for acceptance are scientific content, originality and relevance to biological systems of current interest and importance.
Principal areas of interest include:
- Structure and dynamics of biological macromolecules
- Membrane biophysics and ion channels
- Cell biophysics and organisation
- Macromolecular assemblies
- Biophysical methods and instrumentation
- Advanced microscopics
- System dynamics.
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