Anterior scleral thickness in eyes with central serous chorioretinopathy: A systematic review and meta-analysis.

IF 3 3区医学 Q1 OPHTHALMOLOGY

Acta Ophthalmologica Pub Date : 2026-08-21 DOI:10.1111/aos.70227

Ida Ny Frederiksen, Osman Savran, Rodrigo Anguita, Lasse J Cehofski, Jay Chhablani, Elon H C van Dijk, Lorenzo Ferro Desideri, Paolo Forte, Hideki Koizumi, Danson V Muttuvelu, Marie L R Rasmussen, Gregor S Reiter, Özge Yanik, Yousif Subhi

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Abstract

Purpose: To investigate anterior scleral thickness (AST) as a potential anatomical biomarker for central serous chorioretinopathy (CSC) by synthesizing the evidence on differences in AST between eyes with CSC and healthy controls through a systematic review and meta-analysis.

Methods: A systematic literature search was conducted across multiple databases in January 2026. Observational studies comparing AST measured using optical coherence tomography in eyes with CSC and healthy controls were included. Data were extracted independently by two reviewers. Random-effects meta-analyses were performed using standardized mean differences (SMD, Cohen's d). Risk of bias was assessed using the Agency for Healthcare Research and Quality checklist.

Results: Eight studies comprising 805 individuals (454 CSC, 351 controls) were included in the qualitative synthesis, seven of which were eligible for meta-analysis. AST was significantly higher in eyes with CSC compared with controls in all quadrants: temporal (SMD 0.57, 95% CI 0.40-0.75), nasal (SMD 0.48, 95% CI 0.25-0.71), superior (SMD 0.28, 95% CI 0.04-0.53), and inferior (SMD 0.32, 95% CI 0.08-0.57). Analysis for the temporal quadrant showed low heterogeneity. Findings were robust in sensitivity analyses, and funnel plot assessment did not reveal substantial asymmetry.

Conclusion: Eyes with CSC exhibited increased AST compared with healthy controls. These findings support a potential role for scleral morphology in CSC pathophysiology.

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中枢性浆液性脉络膜视网膜病变的前巩膜厚度：一项系统回顾和荟萃分析。

目的：通过系统综述和荟萃分析，综合CSC患者眼与健康对照眼之间AST差异的证据，探讨前巩膜厚度（AST）作为中枢浆液性脉络膜视网膜病变（CSC）的潜在解剖学生物标志物。方法：于2026年1月对多个数据库进行系统文献检索。比较使用光学相干断层扫描在CSC和健康对照眼中测量AST的观察性研究包括在内。数据由两位审稿人独立提取。随机效应荟萃分析采用标准化平均差异（SMD, Cohen’s d）。使用医疗保健研究和质量检查表评估偏倚风险。结果：8项研究包括805名个体（454名CSC， 351名对照）被纳入定性综合，其中7项符合meta分析的条件。在所有象限中，CSC患者的AST均显著高于对照组：颞部（SMD 0.57, 95% CI 0.40-0.75）、鼻部（SMD 0.48, 95% CI 0.25-0.71）、上眼（SMD 0.28, 95% CI 0.04-0.53）和下眼（SMD 0.32, 95% CI 0.08-0.57）。时间象限的分析显示异质性较低。敏感性分析的结果是稳健的，漏斗图评估没有显示出实质性的不对称性。结论：与健康对照相比，CSC患者的AST明显增加。这些发现支持了巩膜形态在CSC病理生理中的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Ophthalmologica 医学-眼科学

CiteScore

7.60

自引率

5.90%

发文量

433

审稿时长

6 months

期刊介绍： Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.