Efficacy of advanced treatment modalities of dentin hypersensitivity: A systematic review and meta-analysis

Q1 Medicine

Journal of oral biology and craniofacial research Pub Date : 2026-07-01 Epub Date: 2026-08-17 DOI:10.1016/j.jobcr.2026.101500

Vrinda Saxena, Saina Shoukath, Payal Saxena, Suruchi Jatol-Tekade, Sweta M. Kumari, Kiran Bachani, Shivam Kamthan

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引用次数: 0

Abstract

Background

Dentin hypersensitivity (DH) is a prevalent clinical condition characterized by short, sharp pain arising from exposed dentin in response to thermal, tactile, osmotic, or chemical stimuli. Conventional desensitizing agents often provide temporary relief, with inconsistent long-term effectiveness, prompting growing interest in advanced treatment modalities.

Objective

To systematically evaluate and compare the efficacy of advanced treatment modalities with conventional or placebo interventions in reducing dentin hypersensitivity in adults.

Methods

This systematic review and meta-analysis was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (Registration ID: CRD420250651753). Electronic searches were performed in PubMed/MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), and Google Scholar, with the date of final search being 30 September 2025. Randomized controlled trials involving adults with clinically diagnosed dentin hypersensitivity affecting permanent teeth were included. Advanced interventions such as laser therapy, photobiomodulation, bioactive glass, nano-hydroxyapatite, CPP-ACP, iontophoresis, Resin and varnish systems, were assessed. The primary outcome was reduction in hypersensitivity measured using validated pain assessment scales. Risk of bias was evaluated using the Cochrane RoB 2.0 tool, and quantitative synthesis was performed using a RevMan 5.4. software.

Results

Thirty-one randomized controlled trials were included in the qualitative synthesis, and twenty-five studies were eligible for meta-analysis. Advanced treatment modalities demonstrated a statistically significant reduction in dentin hypersensitivity compared with conventional or placebo controls (pooled SMD = −1.02; 95% CI: −1.32 to −0.73; p < 0.001). Laser-based therapies showed the greatest effectiveness, followed by nano-hydroxyapatite and bioactive glass agents. Moderate heterogeneity was observed across studies.

Conclusion

Advanced treatment modalities are more effective than conventional desensitizing agents in managing dentin hypersensitivity. Laser therapy provides the most consistent and sustained relief, supporting its clinical use, while further standardized long-term trials are recommended.

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牙本质过敏的先进治疗方式的疗效：系统回顾和荟萃分析

牙本质过敏（DH）是一种常见的临床症状，其特征是暴露的牙本质在热、触觉、渗透或化学刺激下引起短暂的尖锐疼痛。传统的脱敏剂通常提供暂时的缓解，长期效果不一致，这促使人们对先进治疗方式的兴趣日益浓厚。目的系统评价和比较先进治疗方式与常规或安慰剂干预对降低成人牙本质过敏的疗效。方法本系统评价和荟萃分析按照PRISMA 2020指南进行，并在PROSPERO注册（注册ID: CRD420250651753）。在PubMed/MEDLINE、Cochrane Central Register of Controlled Trials （Central）和谷歌Scholar中进行电子检索，最终检索日期为2025年9月30日。纳入临床诊断为恒牙牙本质过敏的成人随机对照试验。评估了先进的干预措施，如激光治疗、光生物调节、生物活性玻璃、纳米羟基磷灰石、pcp - acp、离子电泳、树脂和清漆系统。主要结果是使用经过验证的疼痛评估量表测量超敏反应的减少。使用Cochrane RoB 2.0工具评估偏倚风险，并使用RevMan 5.4进行定量综合。软件。结果31项随机对照试验纳入定性综合，25项研究符合meta分析。与常规或安慰剂对照组相比，先进的治疗方式显示牙本质过敏的统计学显著降低（合并SMD = - 1.02;95% CI: - 1.32至- 0.73;p <； 0.001）。激光治疗效果最好，其次是纳米羟基磷灰石和生物活性玻璃剂。各研究均观察到中度异质性。结论先进的治疗方法对牙本质过敏的治疗效果优于传统的脱敏药物。激光治疗提供了最一致和持续的缓解，支持其临床使用，同时建议进一步标准化的长期试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of oral biology and craniofacial research Medicine-Otorhinolaryngology

CiteScore

4.90

自引率

0.00%

发文量

133

审稿时长

167 days

期刊介绍： Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.