Cerebrovascular Accident Risk in Survivors of Head and Neck Cancer

IF 15.5 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Jacc: Cardiooncology Pub Date : 2026-08-01 Epub Date: 2026-08-18 DOI:10.1016/j.jaccao.2026.06.003

Courtney Pisano DO, MS, MPH, Jenica Upshaw MD, Benjamin Colvard MD, David Zidar MD, PhD, Ryan Hughes MD, Karem Harth MD, Sahil Parikh MD, Theodore Arsenault PhD, Kamal Chemali MD, Natalie Evans MD, Matthew Mirsky MD, Eli Scher MD, Christopher Murphy MSN, CNP, Logan Cho MD, Jennifer Dorth MD, MHSc

{"title":"Cerebrovascular Accident Risk in Survivors of Head and Neck Cancer","authors":"Courtney Pisano DO, MS, MPH, Jenica Upshaw MD, Benjamin Colvard MD, David Zidar MD, PhD, Ryan Hughes MD, Karem Harth MD, Sahil Parikh MD, Theodore Arsenault PhD, Kamal Chemali MD, Natalie Evans MD, Matthew Mirsky MD, Eli Scher MD, Christopher Murphy MSN, CNP, Logan Cho MD, Jennifer Dorth MD, MHSc","doi":"10.1016/j.jaccao.2026.06.003","DOIUrl":null,"url":null,"abstract":"<div><div>Head and neck cancer survivors treated with radiation therapy have a substantially higher long-term risk of cerebrovascular accident than the general population, driven by radiation-related carotid artery injury, baseline cardiovascular risk factors, and the effects of chemotherapy. Carotid stenosis progresses over time, making regular ultrasound screening important for early detection and intervention. Statin therapy during and after radiation therapy, along with intensive blood pressure management, may reduce cerebrovascular event rates. Guidelines increasingly recommend integrating cardiovascular risk assessment and prevention into cancer care, with special consideration of radiation- and chemotherapy-related risk and aggressive risk factor modification. Multidisciplinary strategies, including medication, lifestyle interventions, and timely revascularization for progressive or symptomatic carotid stenosis, are essential to improve outcomes and minimize cerebrovascular accident risk in head and neck cancer survivors.</div></div>","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"8 4","pages":"Pages 339-356"},"PeriodicalIF":15.5000,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jacc: Cardiooncology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666087326002073","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/8/18 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

Abstract

Head and neck cancer survivors treated with radiation therapy have a substantially higher long-term risk of cerebrovascular accident than the general population, driven by radiation-related carotid artery injury, baseline cardiovascular risk factors, and the effects of chemotherapy. Carotid stenosis progresses over time, making regular ultrasound screening important for early detection and intervention. Statin therapy during and after radiation therapy, along with intensive blood pressure management, may reduce cerebrovascular event rates. Guidelines increasingly recommend integrating cardiovascular risk assessment and prevention into cancer care, with special consideration of radiation- and chemotherapy-related risk and aggressive risk factor modification. Multidisciplinary strategies, including medication, lifestyle interventions, and timely revascularization for progressive or symptomatic carotid stenosis, are essential to improve outcomes and minimize cerebrovascular accident risk in head and neck cancer survivors.

查看原文本刊更多论文

头颈癌幸存者的脑血管意外风险

接受放射治疗的头颈癌幸存者发生脑血管意外的长期风险明显高于一般人群，这是由与放射相关的颈动脉损伤、基线心血管危险因素和化疗的影响所驱动的。颈动脉狭窄随着时间的推移而发展，因此定期进行超声检查对于早期发现和干预非常重要。放疗期间和放疗后他汀类药物治疗，以及强化血压管理，可能会降低脑血管事件发生率。指南越来越多地建议将心血管风险评估和预防纳入癌症治疗，特别考虑放疗和化疗相关的风险和积极的风险因素修改。多学科策略，包括药物治疗，生活方式干预，及时重建进行性或症状性颈动脉狭窄，对于改善头颈癌幸存者的预后和降低脑血管事故风险至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Jacc: Cardiooncology Multiple-

CiteScore

12.50

自引率

6.30%

发文量

106

期刊介绍： JACC: CardioOncology is a specialized journal that belongs to the esteemed Journal of the American College of Cardiology (JACC) family. Its purpose is to enhance cardiovascular care for cancer patients by publishing high-quality, innovative scientific research and sharing evidence-based knowledge. The journal aims to revolutionize the field of cardio-oncology and actively involve and educate professionals in both cardiovascular and oncology fields. It covers a wide range of topics including pre-clinical, translational, and clinical research, as well as best practices in cardio-oncology. Key areas of focus include understanding disease mechanisms, utilizing in vitro and in vivo models, exploring novel and traditional therapeutics (across Phase I-IV trials), studying epidemiology, employing precision medicine, and investigating primary and secondary prevention. Amyloidosis, cardiovascular risk factors, heart failure, and vascular disease are some examples of the disease states that are of particular interest to the journal. However, it welcomes research on other relevant conditions as well.