Electrochemical determination of Ticagrelor based on molecularly imprinted poly dopamine and multi-walled carbon nanotubes/ketjen black nanocomposite

IF 4.7 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research Pub Date : 2026-08-01 Epub Date: 2026-08-10 DOI:10.1016/j.sbsr.2026.101070

Mahmoud Roushani, Zahra Mirzaei Karazan, Saif Ali Ahmed

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引用次数: 0

Abstract

Ticagrelor (TIC) is an antiplatelet drug prescribed for patients with stroke and heart attack. In this research, a selective and novel electrochemical sensor was designed based on glassy carbon electrode modified with ketjen black-multi walled carbon nanotubes nanocomposite and molecularly imprinted polymer (MIP/KB-MWCNTs/GCE) to detect TIC. MIP has been used for the first time to assay TIC drug. The proposed sensor is fabricated through electropolymerization of dopamine (DA) as a monomer and TIC as a template on a substrate of KB-MWCNTs nanocomposite. Electrochemical data were taken on the designed sensor via cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The modified electrode obtained low limit of detection (LOD) 0.016 nM, linear range 0.05 to 2300 nM, acceptable selectivity, repeatability, reproducibility, and stability. The applicability of the sensor was investigated in the analysis of real samples such as serum and urine, with a recovery range of 98.4 to 107.0% and a relative standard deviation (RSD) of less than 2.3%. For validation, the results from the real sample were compared with the spectrophotometric reference method.

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基于分子印迹聚多巴胺和多壁碳纳米管/ketjen黑纳米复合材料的替格瑞洛电化学测定

替格瑞洛（TIC）是一种用于中风和心脏病患者的抗血小板药物。在本研究中，设计了一种基于石墨烯黑-多壁碳纳米管纳米复合材料和分子印迹聚合物修饰的玻碳电极（MIP/KB-MWCNTs/GCE）的选择性新型电化学传感器来检测TIC。MIP首次用于TIC药物的检测。该传感器以多巴胺（DA）为单体，TIC为模板，在KB-MWCNTs纳米复合材料的基底上电聚合而成。通过循环伏安法（CV）和差分脉冲伏安法（DPV）在设计的传感器上获取电化学数据。该电极的检测下限为0.016 nM，线性范围为0.05 ~ 2300 nM，具有良好的选择性、重复性、再现性和稳定性。该传感器在血清、尿液等实际样品分析中的适用性，回收率为98.4 ~ 107.0%，相对标准偏差（RSD）小于2.3%。为了验证，将实际样品的结果与分光光度参考法进行了比较。

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来源期刊

Sensing and Bio-Sensing Research Engineering-Electrical and Electronic Engineering

CiteScore

10.70

自引率

3.80%

发文量

审稿时长

87 days

期刊介绍： Sensing and Bio-Sensing Research is an open access journal dedicated to the research, design, development, and application of bio-sensing and sensing technologies. The editors will accept research papers, reviews, field trials, and validation studies that are of significant relevance. These submissions should describe new concepts, enhance understanding of the field, or offer insights into the practical application, manufacturing, and commercialization of bio-sensing and sensing technologies. The journal covers a wide range of topics, including sensing principles and mechanisms, new materials development for transducers and recognition components, fabrication technology, and various types of sensors such as optical, electrochemical, mass-sensitive, gas, biosensors, and more. It also includes environmental, process control, and biomedical applications, signal processing, chemometrics, optoelectronic, mechanical, thermal, and magnetic sensors, as well as interface electronics. Additionally, it covers sensor systems and applications, µTAS (Micro Total Analysis Systems), development of solid-state devices for transducing physical signals, and analytical devices incorporating biological materials.