Combating Antimicrobial Resistance with Hydrophilic and Eco-Friendly Membrane-Active Antibiotics Derived from Biological Nanoparticles

IF 7.5 Q2 NANOSCIENCE & NANOTECHNOLOGY

ACS Nanoscience Au Pub Date : 2026-08-19 Epub Date: 2026-06-18 DOI:10.1021/acsnanoscienceau.6c00025

Wan Zheng, Hairong Ma, John R. Dutcher, Hongjun Liang

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引用次数: 0

Abstract

The ever-increasing use of antibiotics and the accumulation of antibiotic waste in ecosystems are expediting antimicrobial resistance (AMR). Our next-generation antibiotics should aim for a different antimicrobial mechanism that is less conducive to AMR, a wider therapeutic window tolerant to drug titration, and a quicker deactivation strategy responsive to environmental stimuli. Membrane-active antimicrobials (MAAs) have the potential to thwart AMR, but the lipophilicity of current MAAs gives rise to their broad-spectrum cytotoxicity. Here, we show that biological nanoparticles, such as cyclodextrin and phytoglycogen, can be transformed into potent MAAs with low cytotoxicity by grafting them with hydrophilic polymer brushes. In service, these hydrophilic nanoantibiotics kill bacteria by inducing pore formation exclusively on microbial membranes rich in negative curvature lipids, a bactericidal mode less likely to incur AMR. After service, they are degraded and deactivated by biomass recycling enzymes that are abundant in ecosystems. This study illuminates a new paradigm to combat AMR with hydrophilic and eco-friendly membrane-active antibiotics derived from biological nanoparticles.

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利用生物纳米颗粒衍生的亲水性和环保型膜活性抗生素对抗抗菌素耐药性

抗生素使用的不断增加和生态系统中抗生素废物的积累正在加速抗菌素耐药性（AMR）。我们的下一代抗生素应该致力于一种不同的抗菌机制，减少抗菌素耐药性，更广泛的治疗窗口耐受药物滴定，以及对环境刺激反应更快的失活策略。膜活性抗菌剂（MAAs）具有阻止AMR的潜力，但当前MAAs的亲脂性导致其广谱细胞毒性。在这里，我们发现生物纳米颗粒，如环糊精和植物糖原，可以通过亲水性聚合物刷接枝转化为具有低细胞毒性的强效MAAs。在使用中，这些亲水性纳米抗生素通过在富含负曲率脂质的微生物膜上诱导孔形成来杀死细菌，这是一种不太可能引起抗菌素耐药性的杀菌模式。服务后，它们被生态系统中丰富的生物质循环酶降解和失活。本研究为利用生物纳米颗粒衍生的亲水性和环保型膜活性抗生素对抗抗菌素耐药性提供了一个新的范例。

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来源期刊

ACS Nanoscience Au 材料科学、纳米科学-

CiteScore

4.20

自引率

0.00%

发文量

期刊介绍： ACS Nanoscience Au is an open access journal that publishes original fundamental and applied research on nanoscience and nanotechnology research at the interfaces of chemistry biology medicine materials science physics and engineering.The journal publishes short letters comprehensive articles reviews and perspectives on all aspects of nanoscience and nanotechnology:synthesis assembly characterization theory modeling and simulation of nanostructures nanomaterials and nanoscale devicesdesign fabrication and applications of organic inorganic polymer hybrid and biological nanostructuresexperimental and theoretical studies of nanoscale chemical physical and biological phenomenamethods and tools for nanoscience and nanotechnologyself- and directed-assemblyzero- one- and two-dimensional materialsnanostructures and nano-engineered devices with advanced performancenanobiotechnologynanomedicine and nanotoxicologyACS Nanoscience Au also publishes original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials engineering physics bioscience and chemistry into important applications of nanomaterials.