{"title":"Fetal Vascular Malperfusion: A Comprehensive 10-Year Retrospective Single-Center Cohort Analysis.","authors":"Salah Alwaheeb","doi":"10.1159/mpp/adpag004","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Fetal vascular malperfusion (FVM) represents a significant cause of adverse perinatal outcomes, yet population-specific patterns remain understudied in Middle Eastern populations. This study characterizes FVM patterns and clinical correlates in Kuwait over a 10-year period.</p><p><strong>Methods: </strong>Retrospective analysis of 180 histologically confirmed FVM cases from the Maternity Hospital, Kuwait (2014-2024). Cases were classified by FVM grade, associated pathology, and clinical parameters.</p><p><strong>Results: </strong>High-grade FVM predominated (80.0%, 144/180). Distinct trimester-specific patterns emerged: the second trimester showed the highest inflammatory pathology (18.6%), while maternal vascular malperfusion occurred exclusively in third trimester pregnancies (10.7%). Maternal age analysis revealed an unexpected peak risk in the 30-34 years group (88.3% high-grade FVM). Twin pregnancies demonstrated significantly higher pathological burden (88.9% vs. 79.5% in singletons, p = 0.041).</p><p><strong>Conclusions: </strong>This study reveals distinct FVM patterns in Middle Eastern populations, including unique age-related risks and trimester-specific pathological profiles. These findings support population-specific approaches to FVM assessment and management.</p>","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"1"},"PeriodicalIF":2.2000,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13685644/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/mpp/adpag004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Fetal vascular malperfusion (FVM) represents a significant cause of adverse perinatal outcomes, yet population-specific patterns remain understudied in Middle Eastern populations. This study characterizes FVM patterns and clinical correlates in Kuwait over a 10-year period.
Methods: Retrospective analysis of 180 histologically confirmed FVM cases from the Maternity Hospital, Kuwait (2014-2024). Cases were classified by FVM grade, associated pathology, and clinical parameters.
Results: High-grade FVM predominated (80.0%, 144/180). Distinct trimester-specific patterns emerged: the second trimester showed the highest inflammatory pathology (18.6%), while maternal vascular malperfusion occurred exclusively in third trimester pregnancies (10.7%). Maternal age analysis revealed an unexpected peak risk in the 30-34 years group (88.3% high-grade FVM). Twin pregnancies demonstrated significantly higher pathological burden (88.9% vs. 79.5% in singletons, p = 0.041).
Conclusions: This study reveals distinct FVM patterns in Middle Eastern populations, including unique age-related risks and trimester-specific pathological profiles. These findings support population-specific approaches to FVM assessment and management.
背景：胎儿血管灌注不良（FVM）是不良围产期结局的一个重要原因，但在中东人群中，特定人群的模式仍未得到充分研究。本研究描述了科威特10年来FVM的模式和临床相关性。方法：回顾性分析科威特妇产医院2014-2024年组织学确诊的180例FVM病例。病例根据FVM分级、相关病理和临床参数进行分类。结果：高级别FVM占多数（80.0%,144/180）。不同的妊娠特异性模式出现：妊娠中期炎症病理最高（18.6%），而母体血管灌注不良（MVM）仅发生在妊娠晚期（10.7%）。产妇年龄分析显示，30-34岁组出现意外风险高峰（高级别FVM占88.3%）。双胎妊娠的病理负担明显高于单胎（88.9% vs 79.5%, p = 0.041）。结论：本研究揭示了中东人群中不同的FVM模式，包括独特的年龄相关风险和妊娠期特异性病理特征。这些发现支持针对特定人群的FVM评估和管理方法。
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