NEUROPROTECTIVE FITNESS OF LOSARTAN AGAINST DOXORUBICIN INDUCED NEUROTOXICITY IN WHITE ALBINO RATS.

Abstract

Background: Doxorubicin (Dox) is clinically effective anticancer agent with cytotoxic downside features of neurotoxicity. Losartan (LST), an angiotensin II type 1 receptor blocker (ARB), is antihypertensive with reported pleiotropic effects, hence, the current study was sought to identify the protective effects of losartan in mitigating Dox-induced neurotoxicity in a white Albino rat model.

Methods: Fifty-six adult rats were sub-classified into males and females for each intervention. The groups include control, Dox alone, LST alone, combined Dox and SLT. After sacrificing, the brain was harvested for preparation of slides. Slides were stained and images captured.

Results: Sections from control groups and LST alone were intact in both sexes. Sections from Dox groups in either sex demonstrated moderate to severe tissue changes represented as vascular congestion, glial activation, and focal gliosis. The combination groups of Dox and LST demonstrated restored architecture represented by reduced congestion and gliosis in dose dependent manner with female showing better positive response compared to male.

Conclusion: LST provided histological notable protective effects against Dox insults neurotoxicity in white Albino rats.