Multicystic renal dysplasia with ureteral anomaly and arteritis in a C3-deficient mouse.

IF 1.3 4区农林科学 Q2 VETERINARY SCIENCES

Laboratory Animals Pub Date : 2026-08-17 DOI:10.1177/00236772261469961

Dhanushka Hewapathirana, Christine Goepfert

引用次数: 0

Abstract

A five-week-old female B6.129S4-C3^tm1Crr/J (C3 knockout) mouse presented with abdominal distension and reduced general condition. The animal was euthanized and submitted for necropsy. Gross examination revealed marked dilation of the left kidney and ureter, both containing clear fluid consistent with urine and a focal rupture of the renal capsule with associated uroabdomen. Histopathological evaluation revealed multicystic renal dysplasia characterized by immature glomeruli, primitive tubules, persistent mesenchyme, and dilated collecting ducts, accompanied by a tortuous and dilated ureter. In addition, chronic arteritis was identified in a medium-sized artery within the affected kidney.

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c3缺陷小鼠多囊肾发育不良伴输尿管异常和动脉炎。

5周龄雌性B6.129S4-C3tm1Crr/J （C3敲除）小鼠出现腹胀和一般情况下降。这只动物被安乐死并提交尸检。大体检查显示左肾和输尿管明显扩张，均含有与尿液一致的透明液体，肾包膜局灶性破裂伴尿腹。组织病理学评估显示多囊肾发育不良，其特征是肾小球不成熟，小管原始，间质持久，集尿管扩张，并伴有输尿管弯曲和扩张。此外，在受累肾脏内的一条中等动脉中发现慢性动脉炎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Laboratory Animals 生物-动物学

CiteScore

4.90

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The international journal of laboratory animal science and welfare, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the use of animals in biomedical research. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses on research that reduces the number of animals used or which replaces animal models with in vitro alternatives.