Presumed Secondary Vitreoretinal Lymphoma with Response to Systemic Therapy Alone: Case Report.

IF 0.6 Q4 OPHTHALMOLOGY

Case Reports in Ophthalmology Pub Date : 2026-07-16 eCollection Date: 2026-01-01 DOI:10.1159/000553402

Alyssa C Huelsbeck, Colin P Froines, Julie E Chang, Gordon S Crabtree

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引用次数: 0

Abstract

Introduction: Intraocular lymphoma is a rare malignancy with no standard treatment regimen. We describe a case of secondary vitreoretinal lymphoma (VRL) with excellent response to systemic chemotherapy alone without intravitreal treatment.

Case presentation: A 72-year-old male with a diagnosis of stage IVA diffuse large B-cell lymphoma presented for evaluation of subretinal involvement with visual acuity of 20/20-3 in the right eye and 20/100 in the left eye. Fundus examination was largely unremarkable. Fundus autofluorescence (FAF) showed hyperautofluorescence in the macula with an area of hypoautofluorescence that could not be detected on examination. Ocular coherence tomography showed subretinal material in the macula. A biopsy was deferred, and the treatment plan involved observation of response to systemic chemotherapy. Six-month follow-up showed resolution of the subretinal material and near resolution of the hyperautofluorescence, consistent with response to treatment.

Conclusion: Select cases of isolated secondary VRL may be appropriate for management with systemic chemotherapy alone. Multimodal imaging including FAF can demonstrate lesions that may be less apparent clinically. Imaging may also be used for characterization of lesions when biopsy is deferred.

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假定继发性玻璃体视网膜淋巴瘤仅对全身治疗有反应：病例报告。

眼内淋巴瘤是一种罕见的恶性肿瘤，没有标准的治疗方案。我们描述了一个继发性玻璃体视网膜淋巴瘤（VRL）的病例，其对全身化疗的反应非常好，无需玻璃体内治疗。病例介绍：一名72岁男性，诊断为IVA期弥漫性大b细胞淋巴瘤，右眼视力20/20-3，左眼视力20/100，视网膜下受累。眼底检查基本无明显差异。眼底自身荧光（FAF）在黄斑处显示高自身荧光，伴检查未发现的低自身荧光区。眼相干断层扫描显示黄斑处有视网膜下物质。活检被推迟，治疗计划包括观察对全身化疗的反应。六个月的随访显示视网膜下物质的分辨率和高自身荧光的近分辨率，与治疗反应一致。结论：部分孤立性继发VRL患者可单独进行全身化疗。包括FAF在内的多模态成像可以显示临床上不太明显的病变。当活检推迟时，成像也可用于病变的表征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Case Reports in Ophthalmology OPHTHALMOLOGY-

CiteScore

0.90

自引率

0.00%

发文量

129

审稿时长

12 weeks

期刊介绍： This peer-reviewed online-only journal publishes original case reports covering the entire spectrum of ophthalmology, including prevention, diagnosis, treatment, toxicities of therapy, supportive care, quality-of-life, and survivorship issues. The submission of negative results is strongly encouraged. The journal will also accept case reports dealing with the use of novel technologies, both in the arena of diagnosis and treatment. Supplementary material is welcomed. The intent of the journal is to provide clinicians and researchers with a tool to disseminate their personal experiences to a wider public as well as to review interesting cases encountered by colleagues all over the world. Universally used terms can be searched across the entire growing collection of case reports, further facilitating the retrieval of specific information. Following the open access principle, the entire contents can be retrieved at no charge, guaranteeing easy access to this valuable source of anecdotal information at all times.