Xinyue Dong, Xiao‐Jin Sun, Yi‐Lin Wang, Can Zhang, Xiao‐Tian Wang, Xin‐Ran Shi, Zhan‐Yong Wang
{"title":"Electrochemical Synthesis of Ketones","authors":"Xinyue Dong, Xiao‐Jin Sun, Yi‐Lin Wang, Can Zhang, Xiao‐Tian Wang, Xin‐Ran Shi, Zhan‐Yong Wang","doi":"10.1002/ajoc.70503","DOIUrl":null,"url":null,"abstract":"<div><div>Ketones are important organic compounds. Electrosynthesis offers a mild and sustainable route for ketone synthesis. In this review, rather than summarizing reactions by substrate class or catalytic system, we adopt a mechanistically guided classification based on the origin of the carbonyl oxygen atom. Recent progress is accordingly divided into two categories: (1) transformations using non‐ketone oxygen sources (water, O<sub>2</sub>, CO, CO<sub>2</sub>, TEMPO, alcohols, acids, esters, and aldehydes). (2) functionalization of simple ketone‐containing molecules to access complex ketones. Organizing these methods according to oxygen source provides a unified mechanistic overview and practical guidance for reagent selection.</div></div><div>Ketones are important organic compounds. Electrosynthesis offers a mild and sustainable route for ketone synthesis. In this review, rather than summarizing reactions by substrate class or catalytic system, we adopt a mechanistically guided classification based on the origin of the carbonyl oxygen atom. Recent progress is accordingly divided into two categories: (1) transformations using non‐ketone oxygen sources (water, O<sub>2</sub>, CO, CO<sub>2</sub>, TEMPO, alcohols, acids, esters, and aldehydes). (2) functionalization of simple ketone‐containing molecules to access complex ketones. Organizing these methods according to oxygen source provides a unified mechanistic overview and practical guidance for reagent selection.</div><div>This review focuses on how electrochemistry enables the facile construction of ketones, along with the associated strategies and mechanisms. Recent advances have been summarized via two categories by sources carbonyl oxygen: (1) transformations using non‐ketone oxygen sources (water, O<sub>2</sub>, CO, CO<sub>2</sub>, TEMPO, alcohols, acids, esters, and aldehydes). (2) functionalization of simple ketone‐ containing molecules to access complex ketones.\n<span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (24KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"15 8","pages":"Article e70503"},"PeriodicalIF":2.3000,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S2193580726002370","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/9/10 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Ketones are important organic compounds. Electrosynthesis offers a mild and sustainable route for ketone synthesis. In this review, rather than summarizing reactions by substrate class or catalytic system, we adopt a mechanistically guided classification based on the origin of the carbonyl oxygen atom. Recent progress is accordingly divided into two categories: (1) transformations using non‐ketone oxygen sources (water, O2, CO, CO2, TEMPO, alcohols, acids, esters, and aldehydes). (2) functionalization of simple ketone‐containing molecules to access complex ketones. Organizing these methods according to oxygen source provides a unified mechanistic overview and practical guidance for reagent selection.
Ketones are important organic compounds. Electrosynthesis offers a mild and sustainable route for ketone synthesis. In this review, rather than summarizing reactions by substrate class or catalytic system, we adopt a mechanistically guided classification based on the origin of the carbonyl oxygen atom. Recent progress is accordingly divided into two categories: (1) transformations using non‐ketone oxygen sources (water, O2, CO, CO2, TEMPO, alcohols, acids, esters, and aldehydes). (2) functionalization of simple ketone‐containing molecules to access complex ketones. Organizing these methods according to oxygen source provides a unified mechanistic overview and practical guidance for reagent selection.
This review focuses on how electrochemistry enables the facile construction of ketones, along with the associated strategies and mechanisms. Recent advances have been summarized via two categories by sources carbonyl oxygen: (1) transformations using non‐ketone oxygen sources (water, O2, CO, CO2, TEMPO, alcohols, acids, esters, and aldehydes). (2) functionalization of simple ketone‐ containing molecules to access complex ketones.
期刊介绍：
Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC)
The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
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