{"title":"Yeast single-cell proteins from CO2 with tandem biological systems","authors":"Cheng-Cheng Ding, Pei-Ru Chen, Shu-Guang Wang, Peng-Fei Xia","doi":"10.1016/j.copbio.2026.103567","DOIUrl":null,"url":null,"abstract":"<div><div>Production of customized yeast single-cell protein (SCP) from CO<sub>2</sub> offers a sustainable avenue to convert a major carbon emission process into a carbon-conserving production route of food and feed. Here, we highlight a specific approach for SCP production from CO<sub>2</sub> using sequentially connected yet spatially separated tandem biological systems, which consist of a first unit for CO<sub>2</sub> fixation followed by a second unit for precision fermentation toward customized SCPs. We discuss the design principles of the system, review current efforts to convert CO<sub>2</sub> using natural and engineered autotrophs, and outline the potential of yeast for customized SCP production. Finally, we underscore the critical role of nitrogen sources for efficient SCP production.</div></div>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":"101 ","pages":"Article 103567"},"PeriodicalIF":7.8000,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in biotechnology","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0958166926001321","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/8/13 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
Abstract
Production of customized yeast single-cell protein (SCP) from CO2 offers a sustainable avenue to convert a major carbon emission process into a carbon-conserving production route of food and feed. Here, we highlight a specific approach for SCP production from CO2 using sequentially connected yet spatially separated tandem biological systems, which consist of a first unit for CO2 fixation followed by a second unit for precision fermentation toward customized SCPs. We discuss the design principles of the system, review current efforts to convert CO2 using natural and engineered autotrophs, and outline the potential of yeast for customized SCP production. Finally, we underscore the critical role of nitrogen sources for efficient SCP production.
期刊介绍:
Current Opinion in Biotechnology (COBIOT) is renowned for publishing authoritative, comprehensive, and systematic reviews. By offering clear and readable syntheses of current advances in biotechnology, COBIOT assists specialists in staying updated on the latest developments in the field. Expert authors annotate the most noteworthy papers from the vast array of information available today, providing readers with valuable insights and saving them time.
As part of the Current Opinion and Research (CO+RE) suite of journals, COBIOT is accompanied by the open-access primary research journal, Current Research in Biotechnology (CRBIOT). Leveraging the editorial excellence, high impact, and global reach of the Current Opinion legacy, CO+RE journals ensure they are widely read resources integral to scientists' workflows.
COBIOT is organized into themed sections, each reviewed once a year. These themes cover various areas of biotechnology, including analytical biotechnology, plant biotechnology, food biotechnology, energy biotechnology, environmental biotechnology, systems biology, nanobiotechnology, tissue, cell, and pathway engineering, chemical biotechnology, and pharmaceutical biotechnology.