Epigenetic age acceleration and metabolic syndrome among Hispanic/Latino adults: Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

IF 5.4 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

International Journal of Obesity Pub Date : 2026-08-12 DOI:10.1038/s41366-026-02187-z

Sheroi Johnson, Jorge Gonzalez-Mejia, Jasmine K Aqua, Sydney Pritchard, Robert Kaplan, Jianwen Cai, Carmen R Isasi, Krista M Perreira, Christina Cordero, Linda C Gallo, Humberto Parada, Karen N Conneely, Shakira F Suglia

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引用次数: 0

Abstract

Introduction: We tested the bidirectional association between epigenetic age acceleration (EAA), a marker of biological aging, and metabolic syndrome (MetS), a cluster of conditions that together increase the risk of type 2 diabetes, cardiovascular disease, and other chronic conditions, at different time points.

Methods: A random sample of 962 Hispanic/Latino adults participating in the Hispanic Community Health Study/Study of Latinos were included in the analyses. At baseline, the mean age was 44.8 years, 61.5% of participants were female, and prevalence of MetS was 35.4%. DNA methylation was measured from whole blood, at two different time points six years apart, using the Illumina EPIC BeadChip and epigenetic age and EAA were calculated using the PhenoAge, GrimAge, and DunedinPACE algorithms. MetS was defined using the National Cholesterol Education Program Adult Treatment Panel III guidelines, in which a diagnosis is met when participants meet at least 3 of the 5 conditions: elevated waistline/abdominal obesity, high blood pressure, high blood sugar levels, high blood triglycerides, and low high-density lipoprotein (HDL) cholesterol.

Results: In cross-sectional analyses, higher PhenoAA (PR, 95% CI: 1.03, 1.01, 1.05), GrimAA (PR, 95% CI: 1.05, 1.01, 1.09), and DunedinPACE values (PR, 95% CI: 1.03, 1.02, 1.04) were associated with higher MetS prevalence. Over an average follow-up of six years, higher DunedinPACE values at baseline were associated with higher risk of incident MetS (Risk Ratio (RR), 95% CI: 1.04, 1.02, 1.05). Faster DunedinPACE rates (vs. average) were associated with higher risk of incident MetS (RR, 95% CI: 1.44, 1.07, 1.94), whereas slower DunedinPACE rates (vs. average) were associated with lower risk (RR, 95% CI: 0.44, 0.23, 0.87).

Conclusion: The study suggests EAA is a potential indicator of both prevalent and incident MetS among Hispanic/Latino adults.

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西班牙裔/拉丁裔成年人的表观遗传年龄加速和代谢综合征：西班牙裔社区健康研究/拉丁裔研究（HCHS/SOL）

简介：我们测试了表观遗传年龄加速（EAA）和代谢综合征（MetS）之间的双向关联，表观遗传年龄加速（EAA）是生物学衰老的标志，代谢综合征（MetS）是一组共同增加2型糖尿病、心血管疾病和其他慢性疾病风险的疾病，在不同时间点。方法：随机抽取参加西班牙裔社区健康研究/拉丁裔研究的962名西班牙裔/拉丁裔成年人纳入分析。基线时，平均年龄为44.8岁，61.5%的参与者为女性，met患病率为35.4%。在相隔6年的两个不同时间点，使用Illumina EPIC BeadChip从全血中测量DNA甲基化，并使用PhenoAge， GrimAge和DunedinPACE算法计算表观遗传年龄和EAA。MetS是根据国家胆固醇教育计划成人治疗小组III指南定义的，当参与者满足5种条件中的至少3种时，即符合诊断：腰围升高/腹部肥胖、高血压、高血糖水平、高血脂和低高密度脂蛋白（HDL）胆固醇。结果：在横断面分析中，较高的PhenoAA (PR, 95% CI: 1.03, 1.01, 1.05), GrimAA （PR, 95% CI: 1.05, 1.01, 1.09）和DunedinPACE值（PR, 95% CI: 1.03, 1.02, 1.04）与较高的MetS患病率相关。在平均六年的随访中，基线时较高的DunedinPACE值与较高的met事件风险相关（风险比（RR）， 95% CI: 1.04, 1.02, 1.05）。较快的DunedinPACE率（相对于平均水平）与较高的MetS事件风险相关（RR, 95% CI: 1.44, 1.07, 1.94），而较慢的DunedinPACE率（相对于平均水平）与较低的风险相关（RR, 95% CI: 0.44, 0.23, 0.87）。结论：该研究提示EAA是西班牙裔/拉丁裔成年人中流行和发生MetS的潜在指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Obesity 医学-内分泌学与代谢

CiteScore

10.00

自引率

2.00%

发文量

221

审稿时长

3 months

期刊介绍： The International Journal of Obesity is a multi-disciplinary forum for research describing basic, clinical and applied studies in biochemistry, physiology, genetics and nutrition, molecular, metabolic, psychological and epidemiological aspects of obesity and related disorders. We publish a range of content types including original research articles, technical reports, reviews, correspondence and brief communications that elaborate on significant advances in the field and cover topical issues.