Cuprizone-induced demyelination model mice exhibit antisocial maltreating behavior: an experimental animal study.

Encephalitis (Seoul, Korea) Pub Date : 2026-10-01 Epub Date: 2026-08-13 DOI:10.47936/encephalitis.2026.00052

Daejong Jeon, Sangwoo Kim, Sang Kun Lee, Kon Chu

{"title":"Cuprizone-induced demyelination model mice exhibit antisocial maltreating behavior: an experimental animal study.","authors":"Daejong Jeon, Sangwoo Kim, Sang Kun Lee, Kon Chu","doi":"10.47936/encephalitis.2026.00052","DOIUrl":null,"url":null,"abstract":"Purpose: The structural integrity of white matter in the human brain, including myelination, is important not only for brain pathology but also for cognitive functions, including social behavior. Here, we investigated the relationship between myelination abnormalities and antisocial maltreating behavior in mice.Methods: The demyelination model was generated by feeding cuprizone to C57BL/6 mice. Luxol fast blue staining was performed to visualize myelin. The demyelination model was subjected to a maltreating behavioral task. Oxytocin (OXY), haloperidol (HAL), and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) were used.Results: The demyelination model mice showed a higher number of nose-pokes than the control. OXY or 8-OH-DPAT treatment reduced the high nose-poking number of the demyelination model mice. HAL did not largely affect the number of nose-pokes of the demyelination model mice.Conclusion: Demyelination appears to be closely related to antisocial maltreating behavior. Our maltreating-behavior assay system is a good animal system for investigating brain disorders involving antisocial or psychotic behavior.","PeriodicalId":72904,"journal":{"name":"Encephalitis (Seoul, Korea)","volume":" ","pages":"103-108"},"PeriodicalIF":0.0000,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669865/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Encephalitis (Seoul, Korea)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47936/encephalitis.2026.00052","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/8/13 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: The structural integrity of white matter in the human brain, including myelination, is important not only for brain pathology but also for cognitive functions, including social behavior. Here, we investigated the relationship between myelination abnormalities and antisocial maltreating behavior in mice.

Methods: The demyelination model was generated by feeding cuprizone to C57BL/6 mice. Luxol fast blue staining was performed to visualize myelin. The demyelination model was subjected to a maltreating behavioral task. Oxytocin (OXY), haloperidol (HAL), and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) were used.

Results: The demyelination model mice showed a higher number of nose-pokes than the control. OXY or 8-OH-DPAT treatment reduced the high nose-poking number of the demyelination model mice. HAL did not largely affect the number of nose-pokes of the demyelination model mice.

Conclusion: Demyelination appears to be closely related to antisocial maltreating behavior. Our maltreating-behavior assay system is a good animal system for investigating brain disorders involving antisocial or psychotic behavior.

查看原文本刊更多论文

铜酮诱导脱髓鞘模型小鼠表现出反社会虐待行为：一项实验动物研究。

目的：人脑白质的结构完整性，包括髓鞘形成，不仅对脑部病理很重要，而且对包括社会行为在内的认知功能也很重要。在此，我们研究了小鼠髓鞘异常与反社会虐待行为之间的关系。方法：采用铜酮灌胃法建立C57BL/6小鼠脱髓鞘模型。Luxol快速蓝染色显示髓磷脂。脱髓鞘模型进行虐待行为任务。使用催产素（OXY）、氟哌啶醇（HAL）和8-羟基-2-（二正丙胺）四氢萘（8-OH-DPAT）。结果：脱髓鞘模型小鼠刺鼻次数明显高于对照组。OXY或8-OH-DPAT处理可减少脱髓模型小鼠的高戳鼻次数。HAL对脱髓鞘模型小鼠的戳鼻次数影响不大。结论：脱髓鞘与反社会虐待行为密切相关。我们的虐待行为测定系统是一个很好的动物系统，用于研究涉及反社会或精神病行为的脑部疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Encephalitis (Seoul, Korea)

自引率

0.00%

发文量